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Bombesin stimulates cholecystokinin (CCK) secretion, presumably by a direct effect on the intestinal CCK cell. The present objectives were to characterize bombesin-stimulated CCK release and to investigate the role of calcium in CCK secretion in an intestinal CCK-producing cell line (STC-1). Bombesin caused a dose-dependent release of CCK, which was reduced either in the absence of extracellular calcium or by calcium channel blockade, suggesting that influx of calcium is necessary for CCK secretion. Bombesin caused an increase in intracellular calcium concentration ([Ca2+]i) and increased efflux of 45Ca2+ from 45Ca(2+)-loaded cells. Radioligand binding studies and Northern analysis were consistent with the expression of a bombesin receptor. Thus bombesin stimulation of CCK release occurs via binding to a receptor and is dependent on increased [Ca2+]i. We propose that the STC-1 cell line may provide a useful model for studying the regulation of intestinal CCK secretion.
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V Prpic, and
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S R Vigna, and
R A Liddle
October 1996,
The American journal of physiology,
N D Snow, and
V Prpic, and
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A I Sharara, and
D C McVey, and
L J Hurst, and
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R A Liddle
February 1996,
The American journal of physiology,
N D Snow, and
V Prpic, and
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March 1998,
Endocrinology,
N D Snow, and
V Prpic, and
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A I Sharara, and
D C McVey, and
L J Hurst, and
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R A Liddle
April 2014,
Nutrition research and practice,
N D Snow, and
V Prpic, and
A W Mangel, and
A I Sharara, and
D C McVey, and
L J Hurst, and
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R A Liddle
November 1995,
Biochemical and biophysical research communications,
N D Snow, and
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D C McVey, and
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June 1993,
The American journal of physiology,
N D Snow, and
V Prpic, and
A W Mangel, and
A I Sharara, and
D C McVey, and
L J Hurst, and
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R A Liddle
March 2013,
Biomolecules & therapeutics,
N D Snow, and
V Prpic, and
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A I Sharara, and
D C McVey, and
L J Hurst, and
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R A Liddle
September 1993,
Biochemical and biophysical research communications,
N D Snow, and
V Prpic, and
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D C McVey, and
L J Hurst, and
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R A Liddle
October 2000,
Pancreas,
N D Snow, and
V Prpic, and
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A I Sharara, and
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September 2016,
Fitoterapia,
