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OBJECTIVE Tumor necrosis factor (TNF)-alpha is a multifunctional cytokine that influences the clinical outcome in a number of diseases. This study was undertaken to evaluate its role in the differential diagnosis of malignant and benign tumors and in the follow-up of patients. We also studied the correlation of TNF-alpha levels with the stage and differentiation of the diseases. METHODS In this study, serum levels of TNF-alpha are determined by the immunoradiometric assay method in 26 patients with head and neck cancer, and results are compared with 8 control patients with benign diseases. In both groups, serum samples were taken before and after the therapy. After centrifugation, the sera was stored at -70 degrees C until analyzed. TNF-alpha levels were measured by TNF-alpha immunoradiometric assay (IRMA) kit (Medgenix, Diagnostics SA, Belgium). RESULTS The pretreatment mean value of TNF-alpha in the study group (814.1 pg/mL) was almost 100 times higher than in the control group (8.6 pg/mL) (P = .001). It was also noted that posttreatment mean value (94 pg/mL) was significantly lower than pretreatment mean value in the study group (P = .001). No statistically significant difference was found between serum TNF-alpha levels and the stage and differentiation of the tumor. CONCLUSIONS The serum levels of TNF-alpha may be an efficient tumor marker in the diagnosis of patients with head and neck cancer.
L Soylu, and
C Ozcan, and
F Cetik, and
S Paydaş, and
M Kiroğlu, and
B Aydoğan, and
O Sargin, and
C Ozşahinoglu, and
E Seyrek
April 1992,
The Laryngoscope,
L Soylu, and
C Ozcan, and
F Cetik, and
S Paydaş, and
M Kiroğlu, and
B Aydoğan, and
O Sargin, and
C Ozşahinoglu, and
E Seyrek
July 1994,
The Laryngoscope,
L Soylu, and
C Ozcan, and
F Cetik, and
S Paydaş, and
M Kiroğlu, and
B Aydoğan, and
O Sargin, and
C Ozşahinoglu, and
E Seyrek
November 1995,
American journal of surgery,
L Soylu, and
C Ozcan, and
F Cetik, and
S Paydaş, and
M Kiroğlu, and
B Aydoğan, and
O Sargin, and
C Ozşahinoglu, and
E Seyrek
January 2010,
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes,
L Soylu, and
C Ozcan, and
F Cetik, and
S Paydaş, and
M Kiroğlu, and
B Aydoğan, and
O Sargin, and
C Ozşahinoglu, and
E Seyrek
May 1996,
Archives of otolaryngology--head & neck surgery,
L Soylu, and
C Ozcan, and
F Cetik, and
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O Sargin, and
C Ozşahinoglu, and
E Seyrek
February 2002,
Cancer,
L Soylu, and
C Ozcan, and
F Cetik, and
S Paydaş, and
M Kiroğlu, and
B Aydoğan, and
O Sargin, and
C Ozşahinoglu, and
E Seyrek
November 2002,
Cancer,
L Soylu, and
C Ozcan, and
F Cetik, and
S Paydaş, and
M Kiroğlu, and
B Aydoğan, and
O Sargin, and
C Ozşahinoglu, and
E Seyrek
January 1993,
Biotherapy (Dordrecht, Netherlands),
L Soylu, and
C Ozcan, and
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M Kiroğlu, and
B Aydoğan, and
O Sargin, and
C Ozşahinoglu, and
E Seyrek
March 2009,
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
L Soylu, and
C Ozcan, and
F Cetik, and
S Paydaş, and
M Kiroğlu, and
B Aydoğan, and
O Sargin, and
C Ozşahinoglu, and
E Seyrek
November 2007,
Oral oncology,
