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Apoptosis in normal tissues induced by 5-fluorouracil: comparison between bolus injection and prolonged infusion. 1994
Y Sakaguchi, and
L C Stephens, and
M Makino, and
T Kaneko, and
F R Strebel, and
L L Danhauser, and
G N Jenkins, and
J M Bull
Department of Internal Medicine, University of Texas Medical School, Houston 77225.
The induction of apoptosis in normal tissues was histopathologically examined in rats treated with 5-fluorouracil (5-FU). 5-FU was administered by either bolus intravenous injection or 72-hr prolonged intravenous infusion (PIF). Bolus injection and PIF of 5-FU induced different kinetic profiles of apoptosis in the thymus, spleen and ileum. The bolus injections of 5-FU induced a greater extent of apoptosis in these tissues, compared to PIF 5-FU. These data indicate that the kinetics and extent of apoptosis induced by 5-FU depends on the schedule of the 5-FU administration, and that 5-FU-induced toxicity may be related to 5-FU-induced apoptosis in normal tissues.
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