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The apolipoprotein E epsilon 4 allele has been associated with both familial and sporadic Alzheimer's disease (AD). Given its possible role in nerve repair and growth, it is plausible that apolipoprotein E may be a common denominator in the pathogenesis of several dementing diseases. Therefore, we investigated epsilon 4 frequencies in demented and nondemented alcoholics, as well as in patients with sporadic AD and controls in Japan. No significant differences in allele frequencies was found between demented and nondemented alcoholics and controls, while a significant association was demonstrated between AD and the epsilon 4 allele. These results support a specific role of epsilon 4 in the pathogenesis of AD, rather than a more general role for epsilon 4 in dementing illnesses.
T Muramatsu, and
S Higuchi, and
H Arai, and
H Sasaki, and
K Yamada, and
M Hayashida, and
J Q Trojanowski
January 1994,
Dementia (Basel, Switzerland),
T Muramatsu, and
S Higuchi, and
H Arai, and
H Sasaki, and
K Yamada, and
M Hayashida, and
J Q Trojanowski
August 1994,
Stroke,
T Muramatsu, and
S Higuchi, and
H Arai, and
H Sasaki, and
K Yamada, and
M Hayashida, and
J Q Trojanowski
November 1993,
Lancet (London, England),
T Muramatsu, and
S Higuchi, and
H Arai, and
H Sasaki, and
K Yamada, and
M Hayashida, and
J Q Trojanowski
November 1993,
Lancet (London, England),
T Muramatsu, and
S Higuchi, and
H Arai, and
H Sasaki, and
K Yamada, and
M Hayashida, and
J Q Trojanowski
November 1993,
Lancet (London, England),
T Muramatsu, and
S Higuchi, and
H Arai, and
H Sasaki, and
K Yamada, and
M Hayashida, and
J Q Trojanowski
November 1993,
Lancet (London, England),
T Muramatsu, and
S Higuchi, and
H Arai, and
H Sasaki, and
K Yamada, and
M Hayashida, and
J Q Trojanowski
November 1993,
Lancet (London, England),
T Muramatsu, and
S Higuchi, and
H Arai, and
H Sasaki, and
K Yamada, and
M Hayashida, and
J Q Trojanowski
July 1994,
Israel journal of medical sciences,
T Muramatsu, and
S Higuchi, and
H Arai, and
H Sasaki, and
K Yamada, and
M Hayashida, and
J Q Trojanowski
January 1996,
Genetic epidemiology,
T Muramatsu, and
S Higuchi, and
H Arai, and
H Sasaki, and
K Yamada, and
M Hayashida, and
J Q Trojanowski
January 1998,
Neuroepidemiology,
