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Clinical trial of fusidic acid for lepromatous leprosy. 1994
S G Franzblau, and
G P Chan, and
B G Garcia-Ignacio, and
V E Chavez, and
J B Livelo, and
C L Jimenez, and
M L Parrilla, and
R F Calvo, and
D L Williams, and
T P Gillis
Laboratory Research Branch, Gillis W. Long Hansen's Disease Center, Louisiana State University, Baton Rouge 70894.
Fusidic acid was assessed for antileprosy activity in nine lepromatous leprosy patients. Patients received fusidic acid at either 500 mg/day for 12 weeks or 750 mg/day for 4 weeks followed by 500 mg/day for 8 weeks. All patients showed time-dependent clinical improvement and decreases in bacillary morphological index, radiorespirometric activity and PCR signal, and in serum phenolic glycolipid I. Fusidic acid appears to be a weakly bactericidal antileprosy agent which may have a role in the multidrug treatment of leprosy pending an evaluation of lepra-reaction-suppressive activity.
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