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The reactivities of copper(II) complexes with cimetidine (Cim) and cyclo(histidylhistidyl) (CyHH), both of which are SOD model compounds, toward active oxygen species such as superoxide (O2-) and hydrogen peroxide (H2O2) were investigated by electron spin resonance-spin trapping and thiobarbituric acid methods. At physiological pH values, low concentrations of Cu(II) complexes (0.025 mM) with Cim and CyHH could scavenge O2-, but high concentrations of these compexes (0.25 mM) yielded hydroxyl radicals (.OH) during dismutation of O2-. These Cu(II) complexes could directly react with H2O2 to yield .OH. From these results, it is indicated that .OH formed during the dismutation of O2- by high concentration of SOD model compounds may be caused by the reaction of H2O2 generated form dismutation of O2- with Cu(II) complexes. Further, DNA single-stranded breakage was observed during the reactions of H2O2 with these Cu(II) complexes.
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