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Lung tissue, lymph nodes, and spleen from infants 4-15 weeks old who died of Pneumocystis carinii pneumonia were studied by immunofluorescence and immunoelectron microscopy. The results strongly suggest that antibodies to P. carinii synthetized in lungs by inflammatory infiltrates and in regional lymph nodes are essential in the elimination of P. carinii from infected lungs through their opsonization of the P. carinii organisms. Disintegration of P. carinii conglomerates subsequent to the binding of complement preceded their phagocytosis by lung alveolar macrophages. The immunomorphologic findings strongly supported the hypothesis that the replication of P. carinii at the rate leading to clinical symptoms is due to impaired and delayed synthesis both of antibodies to P. carinii and of complement.
W J Brzosko, and
K Krawczyński, and
K Madaliński, and
A Nowoslawski
April 1964,
American journal of clinical pathology,
W J Brzosko, and
K Krawczyński, and
K Madaliński, and
A Nowoslawski
April 1987,
American journal of clinical pathology,
W J Brzosko, and
K Krawczyński, and
K Madaliński, and
A Nowoslawski
January 1976,
Revista de pediatrie, obstetrica si ginecologie. Pediatria,
W J Brzosko, and
K Krawczyński, and
K Madaliński, and
A Nowoslawski
January 1958,
Virchows Archiv fur pathologische Anatomie und Physiologie und fur klinische Medizin,
W J Brzosko, and
K Krawczyński, and
K Madaliński, and
A Nowoslawski
November 1954,
Hospital (Rio de Janeiro, Brazil),
W J Brzosko, and
K Krawczyński, and
K Madaliński, and
A Nowoslawski
November 1954,
Monatsschrift fur Kinderheilkunde,
W J Brzosko, and
K Krawczyński, and
K Madaliński, and
A Nowoslawski
June 2002,
Planta,
W J Brzosko, and
K Krawczyński, and
K Madaliński, and
A Nowoslawski
August 1978,
MMW, Munchener medizinische Wochenschrift,
W J Brzosko, and
K Krawczyński, and
K Madaliński, and
A Nowoslawski
February 1993,
Annals of allergy,
W J Brzosko, and
K Krawczyński, and
K Madaliński, and
A Nowoslawski
January 1977,
Pneumonologia polska,
