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The reduction of nitroxide free radicals was investigated in detail by Electron Paramagnetic Resonance (EPR) spectroscopy in perfused liver. The nitroxide free radical was rapidly reduced to the corresponding hydroxylamine more efficiently at the lower flow rate of 8 [ml/min], while at higher flow rates, the amount of reduced nitroxide showed a significant decrease. Oxidation of hydroxylamine using hydrogen peroxide provided dynamic information concerning the reduction of the free radical within the liver. In addition, liver homogenates were also investigated to determine the level of nitroxide uptake. The results suggested that a portion of the infused nitroxide was taken up by the liver and cleared from the circulation.
K Nakagawa, and
S Ishida, and
H Yokoyama, and
N Mori, and
S Niwa, and
N Tsuchihashi
August 1973,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
K Nakagawa, and
S Ishida, and
H Yokoyama, and
N Mori, and
S Niwa, and
N Tsuchihashi
September 1984,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
K Nakagawa, and
S Ishida, and
H Yokoyama, and
N Mori, and
S Niwa, and
N Tsuchihashi
April 1986,
The Journal of biological chemistry,
K Nakagawa, and
S Ishida, and
H Yokoyama, and
N Mori, and
S Niwa, and
N Tsuchihashi
October 1993,
Free radical biology & medicine,
K Nakagawa, and
S Ishida, and
H Yokoyama, and
N Mori, and
S Niwa, and
N Tsuchihashi
March 1970,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
K Nakagawa, and
S Ishida, and
H Yokoyama, and
N Mori, and
S Niwa, and
N Tsuchihashi
June 1993,
Cell calcium,
K Nakagawa, and
S Ishida, and
H Yokoyama, and
N Mori, and
S Niwa, and
N Tsuchihashi
September 1988,
Cancer research,
K Nakagawa, and
S Ishida, and
H Yokoyama, and
N Mori, and
S Niwa, and
N Tsuchihashi
January 1970,
Naunyn-Schmiedebergs Archiv fur Pharmakologie,
K Nakagawa, and
S Ishida, and
H Yokoyama, and
N Mori, and
S Niwa, and
N Tsuchihashi
November 1984,
The Biochemical journal,
K Nakagawa, and
S Ishida, and
H Yokoyama, and
N Mori, and
S Niwa, and
N Tsuchihashi
March 1996,
The American journal of physiology,
