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OBJECTIVE For several years, children in Sicily with acute lymphoblastic leukaemia have been treated locally at the University of Catania. We compared the results of locally treated children with the results obtained at other centres. METHODS The diagnosis of acute lymphoblastic leukaemia (ALL) was made in 78 children in the haematology and oncology division of the University of Catania, Sicily, From January 1987 to December 1992. Patients diagnosed before December 1990 were treated with the protocol ALL 87 including prednisone, vincristine, daunorubicine, L-asparaginase and intrathecal methotrexate. Total duration of treatment was 25-26 months. For patients diagnosed after December 1990, the protocol 90-91 used the same drugs for induction and three intrathecal drugs (methotrexate, cytarabine and prednisone) as well as cyclophosphamide to prolong induction in intermediary risk patients. Only high risk patients received cerebral irradiation. Total duration of treatment was 2 years. Full follow-up data were available for 76 patients. RESULTS Survival rate without relapse was 66% and the 5-year survival rate was 82.7%. These results were comparable with those published by other international groups. In addition, particular attention was given to psychological support to decrease the deleterious effects of both the disease and the treatment protocols. CONCLUSIONS These results demonstrate that ALL children can be cared for locally in Sicily without risking poorer outcome. It would be preferable to treat these children as near as possible to their area of residence in order to diminish the psychological trauma resulting from long-term hospitalization far from their family.
A Di Cataldo, and
S P Dibenedetto, and
R Ragusa, and
V Miraglia, and
S D'Amico, and
L Lo Nigro, and
G Schilirò
February 1987,
Gematologiia i transfuziologiia,
A Di Cataldo, and
S P Dibenedetto, and
R Ragusa, and
V Miraglia, and
S D'Amico, and
L Lo Nigro, and
G Schilirò
January 1987,
Revista chilena de pediatria,
A Di Cataldo, and
S P Dibenedetto, and
R Ragusa, and
V Miraglia, and
S D'Amico, and
L Lo Nigro, and
G Schilirò
January 1992,
Pediatrie,
A Di Cataldo, and
S P Dibenedetto, and
R Ragusa, and
V Miraglia, and
S D'Amico, and
L Lo Nigro, and
G Schilirò
June 1976,
Anales espanoles de pediatria,
A Di Cataldo, and
S P Dibenedetto, and
R Ragusa, and
V Miraglia, and
S D'Amico, and
L Lo Nigro, and
G Schilirò
January 1990,
Haematology and blood transfusion,
A Di Cataldo, and
S P Dibenedetto, and
R Ragusa, and
V Miraglia, and
S D'Amico, and
L Lo Nigro, and
G Schilirò
July 1978,
Pediatriia,
A Di Cataldo, and
S P Dibenedetto, and
R Ragusa, and
V Miraglia, and
S D'Amico, and
L Lo Nigro, and
G Schilirò
September 1986,
La Revue du praticien,
A Di Cataldo, and
S P Dibenedetto, and
R Ragusa, and
V Miraglia, and
S D'Amico, and
L Lo Nigro, and
G Schilirò
February 1972,
Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille,
A Di Cataldo, and
S P Dibenedetto, and
R Ragusa, and
V Miraglia, and
S D'Amico, and
L Lo Nigro, and
G Schilirò
May 2007,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
A Di Cataldo, and
S P Dibenedetto, and
R Ragusa, and
V Miraglia, and
S D'Amico, and
L Lo Nigro, and
G Schilirò
January 1991,
Gematologiia i transfuziologiia,
