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Plasma renin activity (PRA), supine, erect and post-frusemide (1 mg/kg IV) was studied in 51 patients with previously untreated essential hypertension and their age- and sex-matched normotensive controls. Supine PRA, and the rise in PRA in response to the erect posture and frusemide, were significantly less in hypertensives compared to controls. When the hypertensives were arbitrarily divided into lower, mid, and upper subgroups according to supine PRA, the renin responsiveness was similar in each subgroup but significantly less in hypertensives compared to controls, subdivided in the same way. This does not support the existence of a separate "low renin" subgroup. The low supine PRA and reduced response to stimulation appears to be a feature of patients with essential hypertension. Thirty-nine of these hypertensives entered a double-blind cross-over drug trial of oxprenolol, methyldopa and spironolactone. All three drugs were equally effective in lowering the systolic and diastolic blood pressures in all three renin subgroups. Spironolactone caused a greater fall in systolic pressure in the lower renin group than in the other groups. Oxprenolol was the best tolerated drug, with only 5% of patients withdrawing due to side-effects compared to 13% on spironolacone and 29% on methyldopa.
G W Thomas, and
J G Ledingham, and
L J Beilin, and
K M Yeates
August 1976,
Australian and New Zealand journal of medicine,
G W Thomas, and
J G Ledingham, and
L J Beilin, and
K M Yeates
June 1975,
Acta medica Scandinavica,
G W Thomas, and
J G Ledingham, and
L J Beilin, and
K M Yeates
January 1977,
Clinical pharmacology and therapeutics,
G W Thomas, and
J G Ledingham, and
L J Beilin, and
K M Yeates
January 1972,
Cleveland Clinic quarterly,
G W Thomas, and
J G Ledingham, and
L J Beilin, and
K M Yeates
January 1983,
Canadian Medical Association journal,
G W Thomas, and
J G Ledingham, and
L J Beilin, and
K M Yeates
January 1977,
Bollettino della Societa italiana di cardiologia,
G W Thomas, and
J G Ledingham, and
L J Beilin, and
K M Yeates
February 2012,
JPMA. The Journal of the Pakistan Medical Association,
G W Thomas, and
J G Ledingham, and
L J Beilin, and
K M Yeates
June 1973,
Wiener klinische Wochenschrift,
G W Thomas, and
J G Ledingham, and
L J Beilin, and
K M Yeates
January 1973,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
G W Thomas, and
J G Ledingham, and
L J Beilin, and
K M Yeates
July 1976,
British medical journal,
