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In adult female rats diabetic nephropathy was induced by i.v. administration of streptozotocin (6 mg/100 g b.w.). The animals survive for 3 weeks when very low daily doses of insulin (0.3 IU/animal) are administered. High blood urea concentrations and distinct proteinuria indicate the impairment of kidney function in streptozotocin diabetic rats. Streptozotocin induces mild polyuria and increased renal excretion of potassium; there is also an increase in renal excretion of administered p-aminohippurate. Three weeks after administration of streptozotocin the formation of lipid peroxides is increased in the kidney. At this time glutathione content (GSH, GSSG) is unchanged in liver and kidney of streptozotocin diabetic rats. Impairment of kidney function in streptozotocin diabetic rats can be prevented by daily supplementation with sufficient doses of insulin (about 3 IU/animal).
H Bräunlich, and
F Marx, and
G Stein
April 1994,
Immunology and cell biology,
H Bräunlich, and
F Marx, and
G Stein
June 1992,
Zeitschrift fur Ernahrungswissenschaft,
H Bräunlich, and
F Marx, and
G Stein
June 2002,
Scandinavian journal of medicine & science in sports,
H Bräunlich, and
F Marx, and
G Stein
June 2007,
Journal of medicinal food,
H Bräunlich, and
F Marx, and
G Stein
January 2005,
Journal of medicinal food,
H Bräunlich, and
F Marx, and
G Stein
November 1997,
Japanese journal of pharmacology,
H Bräunlich, and
F Marx, and
G Stein
September 1999,
Metabolism: clinical and experimental,
H Bräunlich, and
F Marx, and
G Stein
March 2005,
Clinica chimica acta; international journal of clinical chemistry,
H Bräunlich, and
F Marx, and
G Stein
September 1990,
Metabolism: clinical and experimental,
H Bräunlich, and
F Marx, and
G Stein
July 1999,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
