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We have used telomeric DNA to break the human Y chromosome within the centromeric array of alphoid satellite DNA and have created two derivative chromosomes; one consists of the short arm and 140 kb of alphoid DNA, the other consists of the long arm and 480 kb of alphoid DNA. Both segregate accurately at mitosis. It is known that there is no large scale sequence duplication around the alphoid DNA and so the simplest interpretation of our results is that the sequence responsible for accurate segregation is the alphoid DNA itself. Although the long arm acrocentric derivative segregates accurately it lags with respect to the other chromosomes in about 10% of anaphase cells and thus additional sequences may be required for orderly segregation. The short arm acrocentric chromosome is probably no larger than 12 Mb in size and thus our results also demonstrate that chromosomes of this size are capable of accurate segregation.
K E Brown, and
M A Barnett, and
C Burgtorf, and
P Shaw, and
V J Buckle, and
W R Brown
January 1988,
Human heredity,
K E Brown, and
M A Barnett, and
C Burgtorf, and
P Shaw, and
V J Buckle, and
W R Brown
July 1986,
Molekuliarnaia genetika, mikrobiologiia i virusologiia,
K E Brown, and
M A Barnett, and
C Burgtorf, and
P Shaw, and
V J Buckle, and
W R Brown
January 2005,
Nucleic acids research,
K E Brown, and
M A Barnett, and
C Burgtorf, and
P Shaw, and
V J Buckle, and
W R Brown
April 2018,
Nature biotechnology,
K E Brown, and
M A Barnett, and
C Burgtorf, and
P Shaw, and
V J Buckle, and
W R Brown
December 1997,
Chromosoma,
K E Brown, and
M A Barnett, and
C Burgtorf, and
P Shaw, and
V J Buckle, and
W R Brown
January 1998,
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology,
K E Brown, and
M A Barnett, and
C Burgtorf, and
P Shaw, and
V J Buckle, and
W R Brown
December 1989,
American journal of human genetics,
K E Brown, and
M A Barnett, and
C Burgtorf, and
P Shaw, and
V J Buckle, and
W R Brown
April 1994,
Lancet (London, England),
K E Brown, and
M A Barnett, and
C Burgtorf, and
P Shaw, and
V J Buckle, and
W R Brown
January 2014,
PloS one,
K E Brown, and
M A Barnett, and
C Burgtorf, and
P Shaw, and
V J Buckle, and
W R Brown
February 2000,
Human molecular genetics,
