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Recent epidemiologic studies suggested that some histologic types of carcinomas were preferentially induced in the lung by irradiation, whatever the mode of exposure and the radiation quality. Since smoking and other environmental airborne pollutants may be strong confounding factors in humans, we have investigated whether histological subtypes were dependent or not on the mode of exposure, in a large series of 9000 rats exposed to external and internal sources at high and low Linear Energy Transfer. Despite comparable overall risk coefficients in rats and humans, our results show that histological types are influenced not only by dose but also by radiation quality and heterogeneity of dose delivering. We suggest that extrapolation from one group to an other take this information in consideration.
M Morin, and
R Masse, and
J Lafuma
April 1994,
Pathology, research and practice,
M Morin, and
R Masse, and
J Lafuma
November 1981,
Medicina clinica,
M Morin, and
R Masse, and
J Lafuma
January 2003,
Pneumologia (Bucharest, Romania),
M Morin, and
R Masse, and
J Lafuma
January 1988,
Praxis und Klinik der Pneumologie,
M Morin, and
R Masse, and
J Lafuma
January 2023,
Scientific reports,
M Morin, and
R Masse, and
J Lafuma
October 1999,
Cancer,
M Morin, and
R Masse, and
J Lafuma
January 2010,
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery,
M Morin, and
R Masse, and
J Lafuma
December 1994,
Diseases of the colon and rectum,
M Morin, and
R Masse, and
J Lafuma
November 1995,
Diseases of the colon and rectum,
M Morin, and
R Masse, and
J Lafuma
March 2007,
The Journal of thoracic and cardiovascular surgery,
