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We have used molecular genetic methods to examine the status of cell cycle-inhibitory genes in human brain tumors. We found that p16 and a neighboring gene, p15, were often homozygously deleted in glioblastoma multiformes but not in medulloblastomas or ependymomas. The deletions occurred in both primary tumors and their derived xenografts, but no intragenic mutations in either of the two genes were found. The p15 gene was expressed in a more widespread pattern in normal tissues than p16, but the products of both genes had similar capacities to bind to cyclin D-dependent kinases 4 and 6. These data suggest that the target of deletion in glioblastoma multiforme includes both p15 and p16 genes. The reason that homozygous deletions, rather than intragenic mutations, are so common in these tumors may be that deletion is a more efficient mechanism for simultaneous inactivation of both genes.
J Jen, and
J W Harper, and
S H Bigner, and
D D Bigner, and
N Papadopoulos, and
S Markowitz, and
J K Willson, and
K W Kinzler, and
B Vogelstein
October 1995,
Journal of the National Cancer Institute,
J Jen, and
J W Harper, and
S H Bigner, and
D D Bigner, and
N Papadopoulos, and
S Markowitz, and
J K Willson, and
K W Kinzler, and
B Vogelstein
February 2002,
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics,
J Jen, and
J W Harper, and
S H Bigner, and
D D Bigner, and
N Papadopoulos, and
S Markowitz, and
J K Willson, and
K W Kinzler, and
B Vogelstein
October 2000,
Clinica chimica acta; international journal of clinical chemistry,
J Jen, and
J W Harper, and
S H Bigner, and
D D Bigner, and
N Papadopoulos, and
S Markowitz, and
J K Willson, and
K W Kinzler, and
B Vogelstein
April 1997,
International journal of cancer,
J Jen, and
J W Harper, and
S H Bigner, and
D D Bigner, and
N Papadopoulos, and
S Markowitz, and
J K Willson, and
K W Kinzler, and
B Vogelstein
May 1996,
International journal of cancer,
J Jen, and
J W Harper, and
S H Bigner, and
D D Bigner, and
N Papadopoulos, and
S Markowitz, and
J K Willson, and
K W Kinzler, and
B Vogelstein
October 1995,
Blood,
J Jen, and
J W Harper, and
S H Bigner, and
D D Bigner, and
N Papadopoulos, and
S Markowitz, and
J K Willson, and
K W Kinzler, and
B Vogelstein
January 1997,
Journal of neuro-oncology,
J Jen, and
J W Harper, and
S H Bigner, and
D D Bigner, and
N Papadopoulos, and
S Markowitz, and
J K Willson, and
K W Kinzler, and
B Vogelstein
June 2002,
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih,
J Jen, and
J W Harper, and
S H Bigner, and
D D Bigner, and
N Papadopoulos, and
S Markowitz, and
J K Willson, and
K W Kinzler, and
B Vogelstein
February 2003,
Zhonghua yi xue za zhi,
J Jen, and
J W Harper, and
S H Bigner, and
D D Bigner, and
N Papadopoulos, and
S Markowitz, and
J K Willson, and
K W Kinzler, and
B Vogelstein
September 1999,
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi,
