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Oxygen free radicals (OFR) are very reactive and unstable metabolites capable of altering important biomolecules including proteins, lipids and nucleic acids. OFR are regulated by enzymes such as superoxide dismutases (SOD), catalase, glutation peroxidase and by molecules such as vitamins E, A, C, and K, selenio, cystein and other compounds. Increased OFR levels due to an overproduction of these metabolites or to a failure in the control system, induce cellular and tissue injuries that could lead to diseases such as atherosclerosis, arthritis, fibrosis, lung and heart injuries, neurological disorders and cancer. In this article we consider the use of SOD as therapeutic agents both in human and experimental models. We also refer to the administration of SOD as a protective factor against secondary injuries during radiotherapy and to the determination of SOD as a tumor marker.
M Monte, and
E Sacerdote de Lustig
January 2006,
Biomeditsinskaia khimiia,
M Monte, and
E Sacerdote de Lustig
August 1993,
Nihon Sanka Fujinka Gakkai zasshi,
M Monte, and
E Sacerdote de Lustig
February 1990,
Mechanisms of ageing and development,
M Monte, and
E Sacerdote de Lustig
October 1993,
Lancet (London, England),
M Monte, and
E Sacerdote de Lustig
May 1976,
Annals of clinical biochemistry,
M Monte, and
E Sacerdote de Lustig
June 1980,
British journal of cancer,
M Monte, and
E Sacerdote de Lustig
January 1984,
Methods in enzymology,
M Monte, and
E Sacerdote de Lustig
April 2000,
Free radical biology & medicine,
M Monte, and
E Sacerdote de Lustig
November 1975,
The Journal of clinical investigation,
M Monte, and
E Sacerdote de Lustig
August 1974,
Science (New York, N.Y.),
