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A majority of sudden infant death syndrome (SIDS) victims have respiratory or gastrointestinal infections prior to death. This has led to an investigation of the role of pathogenic bacteria and the potentially lethal toxins they produce as triggers for sudden infant death. A small group of bacteria have been consistently identified in SIDS victims as compared to controls, and remarkably, three of these produce superantigenic toxins. Superantigens exert a powerful effect on the immune system, stimulating T-cells, which subsequently induces the formation of large amounts of cytokines. Generation of an overwhelming inflammatory response may lead to death by shock, or other, as yet unrecognized effects of the toxin on the respiratory or cardiac systems. A SIDS/superantigen model is proposed which may explain many of the pathological characteristics of SIDS and establish quantifiable markers for SIDS.
J A Lindsay, and
H M Johnson, and
F M Wallace, and
J M Soos
November 1990,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
J A Lindsay, and
H M Johnson, and
F M Wallace, and
J M Soos
March 2000,
The American journal of medicine,
J A Lindsay, and
H M Johnson, and
F M Wallace, and
J M Soos
February 1991,
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J A Lindsay, and
H M Johnson, and
F M Wallace, and
J M Soos
April 1985,
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J A Lindsay, and
H M Johnson, and
F M Wallace, and
J M Soos
June 1979,
Bruxelles medical,
J A Lindsay, and
H M Johnson, and
F M Wallace, and
J M Soos
May 1989,
BMJ (Clinical research ed.),
J A Lindsay, and
H M Johnson, and
F M Wallace, and
J M Soos
August 1989,
Lakartidningen,
J A Lindsay, and
H M Johnson, and
F M Wallace, and
J M Soos
April 1979,
Medical times,
J A Lindsay, and
H M Johnson, and
F M Wallace, and
J M Soos
January 1992,
Journal de pharmacie de Belgique,
J A Lindsay, and
H M Johnson, and
F M Wallace, and
J M Soos
September 1982,
LARC medical,
