Biomaterial Database

Skin signs of systemic disease. When the problem is more than skin-deep. 1994

C E Holmes, and M C Massa

Loyola University, Chicago Stritch School of Medicine, Maywood, Illinois.

The cutaneous manifestations of systemic diseases are diverse. In some cases, they are the first signs of an underlying disorder, such as Cowden's disease, dermatomyositis, and Lyme disease. Sister Mary Joseph's nodule (metastatic involvement of the umbilicus) is an ominous sign of internal malignant disease. Drug-induced skin necrosis may result from therapy with coumarin (Coumadin, Panwarfin, Sofarin) or heparin.

UI	MeSH Term	Description	Entries
D008193	Lyme Disease	An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.	Lyme Borreliosis,B. burgdorferi Infection,Borrelia burgdorferi Infection,Lyme Arthritis,Arthritis, Lyme,B. burgdorferi Infections,Borrelia burgdorferi Infections,Borreliosis, Lyme,Disease, Lyme
D009336	Necrosis	The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
D003882	Dermatomyositis	A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)	Polymyositis-Dermatomyositis,Dermatomyositis, Adult Type,Dermatomyositis, Childhood Type,Dermatopolymyositis,Juvenile Dermatomyositis,Juvenile Myositis,Adult Type Dermatomyositis,Childhood Type Dermatomyositis,Dermatomyositis, Juvenile,Myositis, Juvenile,Polymyositis Dermatomyositis
D006223	Hamartoma Syndrome, Multiple	A hereditary disease characterized by multiple ectodermal, mesodermal, and endodermal nevoid and neoplastic anomalies. Facial trichilemmomas and papillomatous papules of the oral mucosa are the most characteristic lesions. Individuals with this syndrome have a high risk of BREAST CANCER; THYROID CANCER; and ENDOMETRIAL CANCER. This syndrome is associated with mutations in the gene for PTEN PHOSPHATASE.	Bannayan-Riley-Ruvalcaba Syndrome,Cowden Disease,Cowden's Disease,Lhermitte-Duclos Disease,Multiple Hamartoma Syndrome,PTEN Hamartoma Tumor Syndrome,Bannayan-Ruvalcaba-Riley Syndrome,Bannayan-Zonana Syndrome,Cowden Syndrome,Cowden's Syndrome,Dysplastic Gangliocytoma of Cerebellum,Dysplastic Gangliocytoma of the Cerebellum,Macrocephaly, Multiple Lipomas, and Hemangiomata,Macrocephaly, Pseudopapilledema, and Multiple Hemangiomas,Macrocephaly, Pseudopapilledema, and Multiple Hemangiomata,Myhre-Riley-Smith Syndrome,Riley-Smith Syndrome,Ruvalcaba-Myhre Syndrome,Ruvalcaba-Myhre-Smith Syndrome,Bannayan Riley Ruvalcaba Syndrome,Bannayan Zonana Syndrome,Cerebellum Dysplastic Gangliocytoma,Cerebellum Dysplastic Gangliocytomas,Cowdens Disease,Cowdens Syndrome,Hamartoma Syndromes, Multiple,Lhermitte Duclos Disease,Multiple Hamartoma Syndromes,Myhre Riley Smith Syndrome,Riley Smith Syndrome,Ruvalcaba Myhre Smith Syndrome
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000008	Abdominal Neoplasms	New abnormal growth of tissue in the ABDOMEN.	Abdominal Neoplasm,Neoplasm, Abdominal,Neoplasms, Abdominal
D000925	Anticoagulants	Agents that prevent BLOOD CLOTTING.	Anticoagulant Agent,Anticoagulant Drug,Anticoagulant,Anticoagulant Agents,Anticoagulant Drugs,Anticoagulation Agents,Indirect Thrombin Inhibitors,Agent, Anticoagulant,Agents, Anticoagulant,Agents, Anticoagulation,Drug, Anticoagulant,Drugs, Anticoagulant,Inhibitors, Indirect Thrombin,Thrombin Inhibitors, Indirect
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D012871	Skin Diseases	Diseases involving the DERMIS or EPIDERMIS.	Dermatoses,Skin and Subcutaneous Tissue Disorders,Dermatosis,Skin Disease
D014472	Umbilicus	The pit in the center of the ABDOMINAL WALL marking the point where the UMBILICAL CORD entered in the FETUS.