Biomaterial Database

Effect of a new anti-oestrogen and anti-implantation agent, CDRI-85/287, on tubal transport, development and viability of rat embryos. 1994

S Sreenivasulu, and M M Singh, and V P Kamboj

Central Drug Research Institute, Lucknow, India.

The effect of CDRI-85/287, a pure nonsteroidal anti-oestrogen, on the rate of tubal transport and development and viability of embryos in rats was investigated. Single postcoital oral administration of an anti-implantation dose (2.5 mg kg-1) resulted in a mild acceleration in the passage of embryos through the oviduct; however, their rates of recovery, cleavage, blastocyst formation and zona shedding remained unaffected. Morphologically normal embryos were recovered from the genital tract up to Day 12 post coitum. Embryos recovered from CDRI-85/287-treated rats on Days 4 and 8 post coitum developed to normal term fetuses when transferred to uteri of untreated females. The compound therefore did not seem to have any deleterious direct effect on development or viability of rat embryos.

UI	MeSH Term	Description	Entries
D010064	Embryo Implantation	Endometrial implantation of EMBRYO, MAMMALIAN at the BLASTOCYST stage.	Blastocyst Implantation,Decidual Cell Reaction,Implantation, Blastocyst,Nidation,Ovum Implantation,Blastocyst Implantations,Decidual Cell Reactions,Embryo Implantations,Implantation, Embryo,Implantation, Ovum,Implantations, Blastocyst,Implantations, Embryo,Implantations, Ovum,Nidations,Ovum Implantations
D010066	Ovum Transport	Transport of the OVUM or fertilized ovum (ZYGOTE) from the mammalian oviduct (FALLOPIAN TUBES) to the site of EMBRYO IMPLANTATION in the UTERUS.
D010880	Piperidines	A family of hexahydropyridines.
D001755	Blastocyst	A post-MORULA preimplantation mammalian embryo that develops from a 32-cell stage into a fluid-filled hollow ball of over a hundred cells. A blastocyst has two distinctive tissues. The outer layer of trophoblasts gives rise to extra-embryonic tissues. The inner cell mass gives rise to the embryonic disc and eventual embryo proper.	Embryo, Preimplantation,Blastocysts,Embryos, Preimplantation,Preimplantation Embryo,Preimplantation Embryos
D003282	Contraceptives, Postcoital, Hormonal	Postcoital contraceptives which owe their effectiveness to hormonal preparations.
D004624	Embryo Transfer	The transfer of mammalian embryos from an in vivo or in vitro environment to a suitable host to improve pregnancy or gestational outcome in human or animal. In human fertility treatment programs, preimplantation embryos ranging from the 4-cell stage to the blastocyst stage are transferred to the uterine cavity between 3-5 days after FERTILIZATION IN VITRO.	Blastocyst Transfer,Tubal Embryo Transfer,Tubal Embryo Stage Transfer,Embryo Transfers,Transfer, Embryo,Transfers, Embryo
D004965	Estrogen Antagonists	Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.	Estradiol Antagonists,Antagonists, Estradiol,Antagonists, Estrogen
D005260	Female		Females
D005314	Embryonic and Fetal Development	Morphological and physiological development of EMBRYOS or FETUSES.	Embryo and Fetal Development,Prenatal Programming,Programming, Prenatal
D005328	Fetal Viability	The potential of the FETUS to survive outside the UTERUS after birth, natural or induced. Fetal viability depends largely on the FETAL ORGAN MATURITY, and environmental conditions.	Viability, Fetal