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15-Deoxyspergualin controls cyclosporin- and steroid-resistant intestinal acute graft-versus-host disease after allogeneic bone marrow transplantation. 1994
M Kasai, and
T Higa, and
T Naohara, and
N Masauzi, and
M Watanabe, and
A Matsuura, and
H Ohizumi, and
J Tanaka, and
K Morii, and
Y Kiyama
Sapporo Hokuyu Hospital, Artificial Organ and Transplantation Hospital, Japan.
We report a case of cyclosporin- and methylprednisolone-resistant intestinal acute graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation which responded to a new immunosuppressant, 15-deoxyspergualin (DSG). Endoscopy showed lymphoid hyperplasia with CD3+, CD4+, CD8- lymphocyte infiltration into the submucosa of the jejunum and colon. DSG effectively suppressed this intestinal acute GVHD.
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