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Corneal wound healing following excimer laser keratectomy is the major cause of regression of treatment results. The amount of anterior stromal haze that develops may be influenced by topical medications. Over a period of 6 months, we followed 15 New Zealand white rabbit eyes that underwent excimer laser keratectomy with the VISX 193-nm ArF laser at a fluence of 150 mJ/cm2 for a depth of 130 microns. Eyes were randomized to treatment with prednisolone acetate, diclofenac sodium (Voltaren), a combination of both, and a control group. Drops were administered four times a day for 1 week, two times a day for 3 weeks, and the drops were then tapered. All eyes were reepithelialized by 5 to 7 days. The tandem scanning confocal microscope (TSCM) was used to evaluate the corneal wound in vivo weekly for a month and monthly for 6 months. During the early postoperative period, the TSCM revealed significant anterior stromal keratocyte activation with cell elongation and the spindle-shaped appearance of fibroblasts in all groups. Collagenous stromal scarring was evident initially, then slowly decreased in all treatment groups. This study shows that TSCM is clinically useful for successive in vivo examinations of corneal wounds after excimer laser keratectomy and for comparing the effects of various topical medications.
J P Essepian, and
R K Rajpal, and
D T Azar, and
K New, and
R Antonacci, and
W Shields, and
W J Stark
October 1995,
The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc,
J P Essepian, and
R K Rajpal, and
D T Azar, and
K New, and
R Antonacci, and
W Shields, and
W J Stark
March 2003,
Seminars in ophthalmology,
J P Essepian, and
R K Rajpal, and
D T Azar, and
K New, and
R Antonacci, and
W Shields, and
W J Stark
January 1997,
Transactions of the American Ophthalmological Society,
J P Essepian, and
R K Rajpal, and
D T Azar, and
K New, and
R Antonacci, and
W Shields, and
W J Stark
January 2000,
Journal of refractive surgery (Thorofare, N.J. : 1995),
J P Essepian, and
R K Rajpal, and
D T Azar, and
K New, and
R Antonacci, and
W Shields, and
W J Stark
October 1991,
Archives of ophthalmology (Chicago, Ill. : 1960),
J P Essepian, and
R K Rajpal, and
D T Azar, and
K New, and
R Antonacci, and
W Shields, and
W J Stark
September 1997,
Klinische Monatsblatter fur Augenheilkunde,
J P Essepian, and
R K Rajpal, and
D T Azar, and
K New, and
R Antonacci, and
W Shields, and
W J Stark
September 1992,
Archives of ophthalmology (Chicago, Ill. : 1960),
J P Essepian, and
R K Rajpal, and
D T Azar, and
K New, and
R Antonacci, and
W Shields, and
W J Stark
September 1999,
Cornea,
J P Essepian, and
R K Rajpal, and
D T Azar, and
K New, and
R Antonacci, and
W Shields, and
W J Stark
January 1991,
Developments in ophthalmology,
J P Essepian, and
R K Rajpal, and
D T Azar, and
K New, and
R Antonacci, and
W Shields, and
W J Stark
January 1990,
Refractive & corneal surgery,
