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1. The interactions of dopamine, reserpine and methyldopa on blood pressure of normal subjects and of those with essential hypertension were examined. 2. When biosynthesis of noradrenaline from dopamine was blocked by reserpine, dopamine induced a prominent depressor effect in essential hypertension. 3. The long-term treatment with methyldopa induced a marked potentiateion of the pressor action of domapine in hypertension, although no significant pressor response was found in normal subjects. 4. It is suggested that methylnoradrenaline may accumulate in peripheral nerve endings of patients with essential hypertension in comparison with normal subjects, and this accumulated methylnoradrenaline potentiates the pressor response to dopamine in essential hypertension.
K Abe, and
H Aoyagi, and
M Yasujima, and
S Miyazaki, and
T Kusaka, and
M Seino, and
Y Otsuka, and
N Irokawa, and
S Chiba, and
Y Sakurai, and
K Saito, and
K Yoshinaga
January 1973,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
K Abe, and
H Aoyagi, and
M Yasujima, and
S Miyazaki, and
T Kusaka, and
M Seino, and
Y Otsuka, and
N Irokawa, and
S Chiba, and
Y Sakurai, and
K Saito, and
K Yoshinaga
January 1973,
German medicine,
K Abe, and
H Aoyagi, and
M Yasujima, and
S Miyazaki, and
T Kusaka, and
M Seino, and
Y Otsuka, and
N Irokawa, and
S Chiba, and
Y Sakurai, and
K Saito, and
K Yoshinaga
January 1977,
Verhandlungen der Deutschen Gesellschaft fur Kreislaufforschung,
K Abe, and
H Aoyagi, and
M Yasujima, and
S Miyazaki, and
T Kusaka, and
M Seino, and
Y Otsuka, and
N Irokawa, and
S Chiba, and
Y Sakurai, and
K Saito, and
K Yoshinaga
August 1970,
Lancet (London, England),
K Abe, and
H Aoyagi, and
M Yasujima, and
S Miyazaki, and
T Kusaka, and
M Seino, and
Y Otsuka, and
N Irokawa, and
S Chiba, and
Y Sakurai, and
K Saito, and
K Yoshinaga
January 1983,
American journal of nephrology,
K Abe, and
H Aoyagi, and
M Yasujima, and
S Miyazaki, and
T Kusaka, and
M Seino, and
Y Otsuka, and
N Irokawa, and
S Chiba, and
Y Sakurai, and
K Saito, and
K Yoshinaga
July 1954,
Annals of internal medicine,
K Abe, and
H Aoyagi, and
M Yasujima, and
S Miyazaki, and
T Kusaka, and
M Seino, and
Y Otsuka, and
N Irokawa, and
S Chiba, and
Y Sakurai, and
K Saito, and
K Yoshinaga
January 1982,
Cor et vasa,
K Abe, and
H Aoyagi, and
M Yasujima, and
S Miyazaki, and
T Kusaka, and
M Seino, and
Y Otsuka, and
N Irokawa, and
S Chiba, and
Y Sakurai, and
K Saito, and
K Yoshinaga
January 1988,
Progress in clinical and biological research,
K Abe, and
H Aoyagi, and
M Yasujima, and
S Miyazaki, and
T Kusaka, and
M Seino, and
Y Otsuka, and
N Irokawa, and
S Chiba, and
Y Sakurai, and
K Saito, and
K Yoshinaga
March 1979,
Medical hypotheses,
K Abe, and
H Aoyagi, and
M Yasujima, and
S Miyazaki, and
T Kusaka, and
M Seino, and
Y Otsuka, and
N Irokawa, and
S Chiba, and
Y Sakurai, and
K Saito, and
K Yoshinaga
January 1977,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
