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1. A double-blind cross-over evaluation of the anti-hypertensive effect of metoprolol vs placebo was carried out in a series of twenty-three patients with mild or moderate essential hypertension who were receiving 25 mg of chlorthalidone daily as their basic treatment. An individually determined dose of metoprolol (75-300 mg) was used. 2. Metoprolol, as compared with placebo, produced a statistically significant reduction of blood pressure, both in supine and standing positions. 3. During the double-blind cross-over study mild side effects were more common at the beginning of metoprolol/chlorthalidone treatment than during placebo/chlorthalidone, but these tended to diminish or disappear with time. 4. Metoprolol in combination with chlorathalidone appears to be an effective and well-tolerated treatment for mild and moderate hypertension in patients not responding to chlorthalidone alone.
A Jäättelä, and
K Pyörälä
January 1976,
Duodecim; laaketieteellinen aikakauskirja,
A Jäättelä, and
K Pyörälä
December 1979,
Clinical science (London, England : 1979),
A Jäättelä, and
K Pyörälä
March 1973,
Annales medicinae experimentalis et biologiae Fenniae,
A Jäättelä, and
K Pyörälä
January 1983,
Giornale di clinica medica,
A Jäättelä, and
K Pyörälä
October 1986,
Minerva cardioangiologica,
A Jäättelä, and
K Pyörälä
January 1976,
Duodecim; laaketieteellinen aikakauskirja,
A Jäättelä, and
K Pyörälä
March 1981,
European journal of clinical pharmacology,
A Jäättelä, and
K Pyörälä
January 1983,
Cardiologia (Rome, Italy),
A Jäättelä, and
K Pyörälä
August 1976,
British journal of clinical pharmacology,
A Jäättelä, and
K Pyörälä
January 1981,
Dermatologica,
