-transparent.png){kind=logo}
1. The effects of timolol alone and in combination with a fixed dose of hydrochlorothiazide and amiloride have been studied in a double-blind, controlled study in fifty-four patients with mild to moderate essential hypertension. 2. After a 4 weeks placebo period patients were randomly assigned to enter groups receiving timolol alone (group A), hydrochlorothiazide + amiloride (group B) or timolol + hydrochlorothiazide + amiloride (group C). Each treatment was carried out for 6 weeks. 3. The use of timolol (10 mg), hydrochlorothiazide (25 mg) and amiloride (2-5 mg) in a combination tablet given twice daily gave better control of blood pressure in patients with mild to moderate essential hypertension than did equivalent dosages of timolol alone or of hydrochlorothiazide and amiloride. 4. Clinical and laboratory side effects were minimal.
G Muiesan, and
B Magnani, and
E Agabiti-Rosei, and
C Alicandri, and
E Ambrosioni, and
N Miele
August 1977,
Ugeskrift for laeger,
G Muiesan, and
B Magnani, and
E Agabiti-Rosei, and
C Alicandri, and
E Ambrosioni, and
N Miele
January 1987,
Drug intelligence & clinical pharmacy,
G Muiesan, and
B Magnani, and
E Agabiti-Rosei, and
C Alicandri, and
E Ambrosioni, and
N Miele
March 1978,
L'union medicale du Canada,
G Muiesan, and
B Magnani, and
E Agabiti-Rosei, and
C Alicandri, and
E Ambrosioni, and
N Miele
April 1989,
La Clinica terapeutica,
G Muiesan, and
B Magnani, and
E Agabiti-Rosei, and
C Alicandri, and
E Ambrosioni, and
N Miele
January 1991,
Fundamental & clinical pharmacology,
G Muiesan, and
B Magnani, and
E Agabiti-Rosei, and
C Alicandri, and
E Ambrosioni, and
N Miele
January 1986,
Postgraduate medical journal,
G Muiesan, and
B Magnani, and
E Agabiti-Rosei, and
C Alicandri, and
E Ambrosioni, and
N Miele
June 1977,
Arquivos brasileiros de cardiologia,
G Muiesan, and
B Magnani, and
E Agabiti-Rosei, and
C Alicandri, and
E Ambrosioni, and
N Miele
January 1982,
Current medical research and opinion,
G Muiesan, and
B Magnani, and
E Agabiti-Rosei, and
C Alicandri, and
E Ambrosioni, and
N Miele
January 1994,
Therapie,
G Muiesan, and
B Magnani, and
E Agabiti-Rosei, and
C Alicandri, and
E Ambrosioni, and
N Miele
October 1976,
La Clinica terapeutica,
