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In order to clarify the mechanism of potentiation of cyclophosphamide activity by centrophenoxine, blood concentration of total and activated cyclophosphamide was examined. Blood concentration of cyclophosphamide increased by the compound and biological half-life of activated cyclophosphamide was markedly increased to 30 min from 18 min in intraperitoneal administration. At the same time, concentration of active form in ascites fluid was also increased and biological half-life of the active form was increased to 50 min from 18 min. Similar increase in blood level of active form was also shown by p-chlorophenoxyacetic acid and probenecid, but concentrations at early stages after injection was not increased. As a result, potentiation of cyclophosphamide activity by centrophenoxine was found to be due to maintenance of active form in both blood and ascites fluid at higher levels than those in the control.
F Kanzawa, and
A Hoshi, and
K Kuretani
January 1977,
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F Kanzawa, and
A Hoshi, and
K Kuretani
January 1985,
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F Kanzawa, and
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K Kuretani
January 1984,
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F Kanzawa, and
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K Kuretani
August 1974,
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F Kanzawa, and
A Hoshi, and
K Kuretani
January 1973,
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F Kanzawa, and
A Hoshi, and
K Kuretani
September 1969,
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F Kanzawa, and
A Hoshi, and
K Kuretani
November 1972,
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F Kanzawa, and
A Hoshi, and
K Kuretani
January 1978,
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F Kanzawa, and
A Hoshi, and
K Kuretani
April 1969,
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F Kanzawa, and
A Hoshi, and
K Kuretani
September 1954,
Kiserletes orvostudomany,
