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The various adverse biological effects of vinyl chloride appear to be dependent upon the metabolic conversion of this compound into chemically reactive metabolites. The metabolism of vinyl chloride in mammals and in man, including the formation of monochloroacetic acid and some identified sulfur conjugates is reviewed. Hepatic microsomal mixed function oxidases from rats, mice, and humans were equally effective in transforming vinyl chloride into alkylating agents in vitro. Two of the enzyme reaction products, i.e., chloroethylene oxide and 2-chloroacetaldehyde, showed potent genetic activity in microorganisms and Chinese hamster V79 cells. The role of liver microsomal enzymes in the generation of electrophilic mutagenic vinyl chloride metabolites is discussed.
H Bartsch, and
C Malaveille, and
A Barbin, and
H Bresil, and
L Tomatis, and
R Montesano
July 1978,
Chemico-biological interactions,
H Bartsch, and
C Malaveille, and
A Barbin, and
H Bresil, and
L Tomatis, and
R Montesano
October 1981,
Environmental health perspectives,
H Bartsch, and
C Malaveille, and
A Barbin, and
H Bresil, and
L Tomatis, and
R Montesano
January 1977,
Archives belges de medecine sociale, hygiene, medecine du travail et medecine legale. Belgisch archief van sociale geneeskunde, hygiene, arbeidsgeneeskunde en gerechtelijke geneeskunde,
H Bartsch, and
C Malaveille, and
A Barbin, and
H Bresil, and
L Tomatis, and
R Montesano
October 1979,
Food and cosmetics toxicology,
H Bartsch, and
C Malaveille, and
A Barbin, and
H Bresil, and
L Tomatis, and
R Montesano
October 1981,
British journal of cancer,
H Bartsch, and
C Malaveille, and
A Barbin, and
H Bresil, and
L Tomatis, and
R Montesano
December 1977,
Environmental health perspectives,
H Bartsch, and
C Malaveille, and
A Barbin, and
H Bresil, and
L Tomatis, and
R Montesano
January 1982,
Toxicological European research. Recherche europeenne en toxicologie,
H Bartsch, and
C Malaveille, and
A Barbin, and
H Bresil, and
L Tomatis, and
R Montesano
April 1980,
Food and cosmetics toxicology,
H Bartsch, and
C Malaveille, and
A Barbin, and
H Bresil, and
L Tomatis, and
R Montesano
May 1977,
Journal of toxicology and environmental health,
H Bartsch, and
C Malaveille, and
A Barbin, and
H Bresil, and
L Tomatis, and
R Montesano
January 1980,
Teratogenesis, carcinogenesis, and mutagenesis,
