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The role of interleukin-6 in the bone microenvironment is controversial. We studied the effect of recombinant human interleukin-6 (rhIL-6) administration on bone metabolism in 10 adult female rhesus monkeys (age 12-27 years). Monkeys received rhIL-6 (15 micrograms/kg/day) daily by subcutaneous injection for 28 days. Serum alkaline phosphatase, osteocalcin, and 24 h urinary calcium excretion were determined before, during (at weeks 2 and 4), and after (at week 6) treatment. Transilial biopsies (right and left) were obtained before treatment was initiated and just after the final (28th) dose at week 4. The serum alkaline phosphatase significantly increased at 2 and 4 weeks of rhIL-6 administration. Osteocalcin and urinary calcium excretion significantly decreased at week 2. Upon treatment with rhIL-6 significant reductions in OS/BS and Ob.S/BS were observed without changes in other static histomorphometry parameters. The reductions in urinary calcium excretion, serum osteocalcin, and the static bone parameters are consistent with an IL-6 induced reduction in bone formation or turnover. Whether this pharmacologic effect is relevant at the physiologic level remains to be determined.
N C Binkley, and
W H Sun, and
M M Checovich, and
E B Roecker, and
D B Kimmel, and
W B Ershler
March 1998,
AIDS research and human retroviruses,
N C Binkley, and
W H Sun, and
M M Checovich, and
E B Roecker, and
D B Kimmel, and
W B Ershler
October 1997,
Science in China. Series C, Life sciences,
N C Binkley, and
W H Sun, and
M M Checovich, and
E B Roecker, and
D B Kimmel, and
W B Ershler
August 2004,
Radiation research,
N C Binkley, and
W H Sun, and
M M Checovich, and
E B Roecker, and
D B Kimmel, and
W B Ershler
July 1995,
The Journal of pharmacology and experimental therapeutics,
N C Binkley, and
W H Sun, and
M M Checovich, and
E B Roecker, and
D B Kimmel, and
W B Ershler
October 1989,
The Journal of pharmacology and experimental therapeutics,
N C Binkley, and
W H Sun, and
M M Checovich, and
E B Roecker, and
D B Kimmel, and
W B Ershler
November 1984,
Pharmacology, biochemistry, and behavior,
N C Binkley, and
W H Sun, and
M M Checovich, and
E B Roecker, and
D B Kimmel, and
W B Ershler
December 1994,
Lancet (London, England),
N C Binkley, and
W H Sun, and
M M Checovich, and
E B Roecker, and
D B Kimmel, and
W B Ershler
June 1994,
Brain, behavior, and immunity,
N C Binkley, and
W H Sun, and
M M Checovich, and
E B Roecker, and
D B Kimmel, and
W B Ershler
October 1990,
Drug and alcohol dependence,
N C Binkley, and
W H Sun, and
M M Checovich, and
E B Roecker, and
D B Kimmel, and
W B Ershler
August 1992,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
