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To confirm the clinical utility of selegiline (L-deprenyl), a selective inhibitor of monoamine oxidase B, as an anti-Parkinson's disease (PD) agent, the first Japanese multi-center, double-blind comparative study of this drug was conducted. The subjects were patients who had responded poorly or suffered with other problems related to L-dopa treatment. A total of 112 patients in two groups, one given selegiline at a dose of 7.5 mg/day (Group D, n = 60) and another given a placebo (Group P, n = 52), were compared over an 8-week treatment period. The percentage patients showing "moderate improvement" or better was 34.5% in Group D, while that in Group P was 11.5% (P < 0.01). In the assessment of overall safety, 66.7% in Group D showed no adverse reactions, which was not significantly different from the result of 78.9% for Group P.
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S Yorifuji, and
Y Nakamura, and
N Ogawa
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Acta neurologica Scandinavica,
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H Tachibana, and
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Y Nakamura, and
N Ogawa
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N Ogawa
January 1983,
Acta neurologica Scandinavica. Supplementum,
M Takahashi, and
R Yuasa, and
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Y Nakamura, and
N Ogawa
January 1983,
Acta neurologica Scandinavica. Supplementum,
M Takahashi, and
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Y Nakamura, and
N Ogawa
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M Takahashi, and
R Yuasa, and
T Imai, and
H Tachibana, and
S Yorifuji, and
Y Nakamura, and
N Ogawa
October 1985,
Acta neurologica,
M Takahashi, and
R Yuasa, and
T Imai, and
H Tachibana, and
S Yorifuji, and
Y Nakamura, and
N Ogawa
January 1966,
Acta neurologica Scandinavica,
M Takahashi, and
R Yuasa, and
T Imai, and
H Tachibana, and
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Y Nakamura, and
N Ogawa
October 1989,
Clinical neuropharmacology,
M Takahashi, and
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H Tachibana, and
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Y Nakamura, and
N Ogawa
February 1993,
The American journal of psychiatry,
