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The human gene for the 5-HT1E serotonin receptor was recently cloned, but no chromosomal assignment has yet been given to this gene (locus HTR1E). In this work, we demonstrate by two independent polymerase chain reactions on a panel of human-hamster somatic cell hybrid genomic DNA that the 5-HT1E serotonin receptor gene is localized on human chromosome 6. Furthermore, by means of in situ hybridization to human metaphase chromosomes, using the cloned 5-HT1E receptor gene (phage clone lambda-S31; Levy et al., FEBS Lett. 296:201-206,1992) as was a probe, we demonstrate that this gene is localized to the q14-q15 region on chromosome 6. Screening of genomic DNA from 15 unrelated Caucasian individuals, using as a probe the open reading frame of the cloned 5-HT1E receptor gene, did not reveal any restriction fragment length polymorphisms with the enzymes BamHI, BanII, BglII, EcoRI, HincII, HindIII, HinfI, MspI, PstI, and PvuII. Since the 5-HT1E receptor is found mainly in the cerebral cortex and abnormal function of the serotonergic system has been implicated in a variety of neurologic and psychiatric diseases, the precise chromosomal assignment of the 5-HT1E receptor gene is the crucial first step toward the evaluation of this locus as a candidate for mutations in such syndromes.
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T Gudermann
September 1991,
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F O Levy, and
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Cytogenetics and cell genetics,
F O Levy, and
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Molecular pharmacology,
F O Levy, and
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Human genetics,
F O Levy, and
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Genomics,
F O Levy, and
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Molecular membrane biology,
F O Levy, and
H Holtgreve-Grez, and
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T Gudermann
September 2023,
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F O Levy, and
H Holtgreve-Grez, and
K Taskén, and
R Solberg, and
T Ried, and
T Gudermann
June 1985,
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F O Levy, and
H Holtgreve-Grez, and
K Taskén, and
R Solberg, and
T Ried, and
T Gudermann
March 1990,
Genomics,
