Biomaterial Database

[Molecular construction and biological activities of botulinum toxins (author's transl)]. 1976

G Sakaguchi, and I Ohishi

UI	MeSH Term	Description	Entries
D007408	Intestinal Absorption	Uptake of substances through the lining of the INTESTINES.	Absorption, Intestinal
D008970	Molecular Weight	The sum of the weight of all the atoms in a molecule.	Molecular Weights,Weight, Molecular,Weights, Molecular
D001905	Botulinum Toxins	Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.	Botulin,Botulinum Neurotoxin,Botulinum Neurotoxins,Clostridium botulinum Toxins,Botulinum Toxin,Neurotoxin, Botulinum,Neurotoxins, Botulinum,Toxin, Botulinum,Toxins, Botulinum,Toxins, Clostridium botulinum
D003014	Clostridium botulinum	A species of anaerobic, gram-positive, rod-shaped bacteria in the family Clostridiaceae that produces proteins with characteristic neurotoxicity. It is the etiologic agent of BOTULISM in humans, wild fowl, HORSES; and CATTLE. Seven subtypes (sometimes called antigenic types, or strains) exist, each producing a different botulinum toxin (BOTULINUM TOXINS). The organism and its spores are widely distributed in nature.
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

G Sakaguchi, and I Ohishi

Molecular structures and biological activities of Clostridium botulinum toxins.

April 1974, Japanese journal of medical science & biology,

G Sakaguchi, and I Ohishi

Molecular construction of Clostridium botulinum type A toxins.

December 1975, Infection and immunity,

G Sakaguchi, and I Ohishi

[Molecular constitution and biological activities of endotoxin (author's transl)].

November 1976, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,

G Sakaguchi, and I Ohishi

Proceedings: Molecular construction of Clostridium botulinum type A toxins.

January 1975, Japanese journal of medical science & biology,

G Sakaguchi, and I Ohishi

[Extraction and concentration of Clostridium botulinum toxins from specimens (author's transl)].

March 1976, Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,

G Sakaguchi, and I Ohishi

Comparative activities of tetanus and botulinum toxins.

January 1984, Neuroscience,

G Sakaguchi, and I Ohishi

[Biological membranes: principles of construction and function (author's transl)].

March 1980, Bratislavske lekarske listy,

G Sakaguchi, and I Ohishi

[Biological activities of protease inhibitors (author's transl)].

January 1980, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,

G Sakaguchi, and I Ohishi

[Biological activities of somatostatin analogs (author's transl)].

May 1979, Horumon to rinsho. Clinical endocrinology,