-transparent.png){kind=logo}
The aim of the study was to investigate the plasma concentrations of isotretinoin and its metabolites, at three doses and after single and multiple topical applications of isotretinoin gel (0.05%) in hairless rats. We used a highly sensitive HPLC method for simultaneous determinations of these compounds, with a detection limit of 2 ng/ml in plasma. Isotretinoin and its metabolites were detected after single and multiple cutaneous applications of overdosing (2,000 mg) of isotretinoin gel up to 24 h after the single dose and after the last dose. The plasma concentrations of these compounds were below the limit of quantification in all the animals at all times for the 200- and 20-mg doses.
D Santana, and
H Bun, and
J Joachim, and
A Durand, and
J P Reynier
October 1980,
Postgraduate medical journal,
D Santana, and
H Bun, and
J Joachim, and
A Durand, and
J P Reynier
July 1951,
The Journal of pharmacy and pharmacology,
D Santana, and
H Bun, and
J Joachim, and
A Durand, and
J P Reynier
June 1991,
The Journal of tropical medicine and hygiene,
D Santana, and
H Bun, and
J Joachim, and
A Durand, and
J P Reynier
April 2009,
Theriogenology,
D Santana, and
H Bun, and
J Joachim, and
A Durand, and
J P Reynier
August 2000,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
D Santana, and
H Bun, and
J Joachim, and
A Durand, and
J P Reynier
May 1993,
Arzneimittel-Forschung,
D Santana, and
H Bun, and
J Joachim, and
A Durand, and
J P Reynier
January 1989,
European journal of drug metabolism and pharmacokinetics,
D Santana, and
H Bun, and
J Joachim, and
A Durand, and
J P Reynier
September 1990,
The American journal of clinical nutrition,
D Santana, and
H Bun, and
J Joachim, and
A Durand, and
J P Reynier
January 2015,
Dermatology (Basel, Switzerland),
D Santana, and
H Bun, and
J Joachim, and
A Durand, and
J P Reynier
January 1985,
Biopharmaceutics & drug disposition,
