In Côte d'Ivoire, 88 patients of a series of 124 cases with Buruli ulcer have been able to be treated and supervised. All of them have received local cares and various antibiotics, and 23 have been treated by islet skin graft. Among the numerous antibiotics used, only Streptomycin seems to be accompanied by an acceptable failure rate. The islet-graft presents the advantage of the technical simplicity, of the good tolerance face the infection and of a good successful rate, which permits to shorten the evolution of this disabling affection. It seems to be the best adapted procedure taking into account available medical means in most of tropical countries.