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Plasma fibrinogen was determined in 189 twins participating at the Indiana center during the third examination of the NHLBI twin study with a mean age of 63 years. Moderate heritability estimates were obtained from 44 complete MZ pairs and 39 complete DZ pairs. After adjustment of fibrinogen levels for age and other confounding variables related to cardiovascular disease risk, the maximum likelihood heritability estimate was only 30% (p = 0.03). Plasma fibrinogen was most strongly associated with smoking and the presence of diabetes. Omitting all subjects with diabetes or cardiovascular disease further reduced the heritability estimates slightly, and most path models including genetic parameters provided no significant improvement in fit over a model determined solely by random environmental effects. Our results are consistent with the environment rather than genetic influences having a greater influence on the level of plasma fibrinogen.
T Reed, and
R P Tracy, and
R R Fabsitz
January 1991,
Annals of human biology,
T Reed, and
R P Tracy, and
R R Fabsitz
January 1991,
Acta geneticae medicae et gemellologiae,
T Reed, and
R P Tracy, and
R R Fabsitz
May 1988,
American journal of epidemiology,
T Reed, and
R P Tracy, and
R R Fabsitz
November 2006,
Aviation, space, and environmental medicine,
T Reed, and
R P Tracy, and
R R Fabsitz
January 1991,
Behavior genetics,
T Reed, and
R P Tracy, and
R R Fabsitz
February 2023,
Twin research and human genetics : the official journal of the International Society for Twin Studies,
T Reed, and
R P Tracy, and
R R Fabsitz
May 2007,
Clinical chemistry,
T Reed, and
R P Tracy, and
R R Fabsitz
March 2003,
Journal of the American Academy of Child and Adolescent Psychiatry,
T Reed, and
R P Tracy, and
R R Fabsitz
April 1996,
BMJ (Clinical research ed.),
T Reed, and
R P Tracy, and
R R Fabsitz
January 2004,
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity,
