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OBJECTIVE To investigate whether application of "early" photodynamic therapy (PDT) using a disulphonated aluminium phthallocyanine photosensitizer can potentiate the action of melphalan in experimental RIF-1 tumors in vivo. METHODS Tumors were irradiated with laser light of wavelength 675 nm 60 min after treatment with the photosensitizer and 15 min after melphalan. Melphalan pharmacokinetics were measured using high performance liquid chromatography with optical detection. RESULTS Melphalan and PDT when given alone, caused a significant delay in tumor growth. This was increased for the combined treatment. Pharmacokinetic analyses showed that levels of free, unreacted melphalan in freely circulating blood are unaffected by combined treatment. However, significant differences in tumor levels were observed between treatment with melphalan alone or in combination. Whereas in the former, melphalan is still present in tumors after 2 h, it was not detectable even at the earliest time of 15-23 min for the combined treatment. CONCLUSIONS The antitumor effects were additive with no evidence of significant potentiation.
J M Sansom, and
B Sutton, and
N Reeves, and
J K Bradley, and
P J Wood, and
J C Bremner, and
G E Adams, and
I J Stratford
January 1984,
Critical reviews in oncology/hematology,
J M Sansom, and
B Sutton, and
N Reeves, and
J K Bradley, and
P J Wood, and
J C Bremner, and
G E Adams, and
I J Stratford
January 2015,
Molecular pharmaceutics,
J M Sansom, and
B Sutton, and
N Reeves, and
J K Bradley, and
P J Wood, and
J C Bremner, and
G E Adams, and
I J Stratford
January 2013,
Clinical endoscopy,
J M Sansom, and
B Sutton, and
N Reeves, and
J K Bradley, and
P J Wood, and
J C Bremner, and
G E Adams, and
I J Stratford
January 2018,
Journal of pharmaceutical investigation,
J M Sansom, and
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N Reeves, and
J K Bradley, and
P J Wood, and
J C Bremner, and
G E Adams, and
I J Stratford
December 1994,
International journal of oral and maxillofacial surgery,
J M Sansom, and
B Sutton, and
N Reeves, and
J K Bradley, and
P J Wood, and
J C Bremner, and
G E Adams, and
I J Stratford
December 2016,
Journal of biophotonics,
J M Sansom, and
B Sutton, and
N Reeves, and
J K Bradley, and
P J Wood, and
J C Bremner, and
G E Adams, and
I J Stratford
September 2016,
Nihon rinsho. Japanese journal of clinical medicine,
J M Sansom, and
B Sutton, and
N Reeves, and
J K Bradley, and
P J Wood, and
J C Bremner, and
G E Adams, and
I J Stratford
February 1997,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
J M Sansom, and
B Sutton, and
N Reeves, and
J K Bradley, and
P J Wood, and
J C Bremner, and
G E Adams, and
I J Stratford
November 2020,
Cancers,
J M Sansom, and
B Sutton, and
N Reeves, and
J K Bradley, and
P J Wood, and
J C Bremner, and
G E Adams, and
I J Stratford
October 2016,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
