BIOMAT Database Logo BIOMAT Database Logo

Renal and hormonal responses to repeated treatment with enalapril in non-azotemic cirrhosis with ascites. 1994

A Ohnishi, and S Murakami, and M Harada, and K Osaka, and K Wada, and M Odagiri, and T Tsuchiya, and T Tanaka
Department of Internal Medicine (I), Daisan Hospital, Jikei University School of Medicine, Tokyo, Japan.

Since a single dose of the angiotensin-converting enzyme inhibitor enalapril was shown to cause natriuresis in cirrhosis in a previous study, we investigated whether repeated doses of this substance would sustain a favorable renal effect in cirrhosis. Ten milligrams of enalapril maleate were administered once a day for 8 days to ten patients with non-azotemic cirrhosis and ascites. Enalapril reduced blood pressure significantly at 4 to 12 h (systolic blood pressure) and 2, 6, and 8 h (diastolic blood pressure) on day 2, compared to pretreatment (day 0) values, but this depressor effect decreased on day 8. No change in heart rate could be detected. Enalapril significantly suppressed serum angiotensin-converting enzyme activity and plasma aldosterone concentration (p < 0.001 to 0.01), which were elevated prior to treatment, with pretreatment values of 25.8 +/- 1.8 IU/l for serum angiotensin-converting enzyme activity and 241 +/- 67 pg/ml for plasma aldosterone concentration. This drug caused a 12 to 24% increase (p < 0.05 to 0.01) in mean daily urinary volume and a 40 to 54% increase (p < 0.001 to 0.01) in mean daily urinary sodium excretion from the respective pretreatment baselines during the 8-day period. Creatinine clearance was improved (p < 0.05) by the treatment, with mean improvement values from 24 to 34% above the pretreatment value of 47.4 +/- 4.3 ml/min.(ABSTRACT TRUNCATED AT 250 WORDS)

UI MeSH Term Description Entries
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D007703 Peptidyl-Dipeptidase A A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of ANGIOTENSIN I to ANGIOTENSIN II, with increase in vasoconstrictor activity, but no action on angiotensin II. It is also able to inactivate BRADYKININ, a potent vasodilator; and has a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. (From https://www.uniprot.org April 15, 2020). ACE1 Angiotensin-Converting Enzyme 1,ACE1 Protein,Angiotensin Converting Enzyme,Angiotensin Converting Enzyme 1,Antigens, CD143,CD143 Antigens,Dipeptidyl Carboxypeptidase I,Kininase II,Peptidase P,Angiotensin I-Converting Enzyme,Carboxycathepsin,Dipeptidyl Peptidase A,Kininase A,ACE1 Angiotensin Converting Enzyme 1,Angiotensin I Converting Enzyme,Carboxypeptidase I, Dipeptidyl,Peptidyl Dipeptidase A
D008103 Liver Cirrhosis Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. Cirrhosis, Liver,Fibrosis, Liver,Hepatic Cirrhosis,Liver Fibrosis,Cirrhosis, Hepatic
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009318 Natriuresis Sodium excretion by URINATION. Natriureses
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D003404 Creatinine Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D004656 Enalapril An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE. Enalapril Maleate,MK-421,MK421,Renitec,Renitek,MK 421,Maleate, Enalapril
D005260 Female Females

Related Publications

A Ohnishi, and S Murakami, and M Harada, and K Osaka, and K Wada, and M Odagiri, and T Tsuchiya, and T Tanaka
Renal effects of treatment with diuretics, octreotide or both, in non-azotemic cirrhotic patients with ascites.
August 2005, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
A Ohnishi, and S Murakami, and M Harada, and K Osaka, and K Wada, and M Odagiri, and T Tsuchiya, and T Tanaka
Treatment of ascites and renal failure in cirrhosis.
January 1989, Bailliere's clinical gastroenterology,
A Ohnishi, and S Murakami, and M Harada, and K Osaka, and K Wada, and M Odagiri, and T Tsuchiya, and T Tanaka
[Renal, hemodynamic and hormonal effects of repeated water immersion in liver cirrhosis].
January 1990, Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR,
A Ohnishi, and S Murakami, and M Harada, and K Osaka, and K Wada, and M Odagiri, and T Tsuchiya, and T Tanaka
Effects of a 7-day treatment with midodrine in non-azotemic cirrhotic patients with and without ascites.
February 2007, Journal of hepatology,
A Ohnishi, and S Murakami, and M Harada, and K Osaka, and K Wada, and M Odagiri, and T Tsuchiya, and T Tanaka
Serum glucagon and cystatin C levels with renal doppler sonography findings in non-azotemic liver cirrhosis cases.
January 2011, Hepato-gastroenterology,
A Ohnishi, and S Murakami, and M Harada, and K Osaka, and K Wada, and M Odagiri, and T Tsuchiya, and T Tanaka
Ascites and renal functional abnormalities in cirrhosis. Pathogenesis and treatment.
June 1997, Bailliere's clinical gastroenterology,
A Ohnishi, and S Murakami, and M Harada, and K Osaka, and K Wada, and M Odagiri, and T Tsuchiya, and T Tanaka
Haemodynamic and hormonal responses to oral enalapril in salt depleted normotensive man.
March 1993, British journal of clinical pharmacology,
A Ohnishi, and S Murakami, and M Harada, and K Osaka, and K Wada, and M Odagiri, and T Tsuchiya, and T Tanaka
Cardiovascular, renal, and neurohumoral responses to single large-volume paracentesis in patients with cirrhosis and diuretic-resistant ascites.
March 1997, The American journal of gastroenterology,
A Ohnishi, and S Murakami, and M Harada, and K Osaka, and K Wada, and M Odagiri, and T Tsuchiya, and T Tanaka
Renin, aldosterone and renal haemodynamics in cirrhosis with ascites.
February 1979, European journal of clinical investigation,
A Ohnishi, and S Murakami, and M Harada, and K Osaka, and K Wada, and M Odagiri, and T Tsuchiya, and T Tanaka
[Functional renal failure in liver cirrhosis with ascites].
January 1981, Vnitrni lekarstvi,
Copied contents to your clipboard!