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Twenty nine 1-(2-[(4-substituted-phenyl) methoxy]-2-(substituted-phenyl) ethyl)-1H-azoles were synthesized for searching of more potent and less toxic antimycotic agents. Nine of the title compounds are first reported. Results of preliminary biological tests showed that most of the title compounds exhibited activity against the common pathogenic fungi such as Candida albicans, Microsporum bodin, Trichophyton gypsum, Epidermophyton floccosum, Trichophyton violaceum, Microsporum ferrugincum, Trichophyton rubrum and Microsporum gypsum. The antifungal activity of compound 14 was roughly comparable to clotrimazole and econazole against Candida albicans, but was more active against other test fungi than clotrimazole and econazole. Compounds 4, 5, 6, 12, 23 also have good antifungal activity, but are less active against Candida albicans.
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