-transparent.png){kind=logo}
The effect of mangiferin, a tetrahydroxy pyrrolidone saponin extracted from the leaves of mango (Mangifera indica), against herpes simplex virus type 2 (HSV-2) in vitro was studied. The 50% effective concentration (EC50) of it against HSV-2 plaque formation in HeLa cells was 111.7 micrograms.ml-1, and the concentrations of 33 and 80 micrograms.ml-1 reduced the virus replicative yields by 90% (EC90) and 99% (EC99), respectively. The therapeutic index (IC50/EC50) was 8.1. Mangiferin did not directly inactivate HSV-2. The results of the drug addition and removal tests suggest that mangiferin inhibits the late event in HSV-2 replication.
Related Publications
X M Zhu, and
J X Song, and
Z Z Huang, and
Y M Wu, and
M J Yu
January 1992,
Archives of virology,
X M Zhu, and
J X Song, and
Z Z Huang, and
Y M Wu, and
M J Yu
June 2023,
Biotechnology reports (Amsterdam, Netherlands),
X M Zhu, and
J X Song, and
Z Z Huang, and
Y M Wu, and
M J Yu
February 2002,
Journal of medical virology,
X M Zhu, and
J X Song, and
Z Z Huang, and
Y M Wu, and
M J Yu
December 2002,
Antiviral research,
X M Zhu, and
J X Song, and
Z Z Huang, and
Y M Wu, and
M J Yu
October 2019,
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences,
X M Zhu, and
J X Song, and
Z Z Huang, and
Y M Wu, and
M J Yu
June 2018,
Journal of microbiology and biotechnology,
X M Zhu, and
J X Song, and
Z Z Huang, and
Y M Wu, and
M J Yu
March 1992,
Bioscience, biotechnology, and biochemistry,
X M Zhu, and
J X Song, and
Z Z Huang, and
Y M Wu, and
M J Yu
January 2022,
Drug design, development and therapy,
X M Zhu, and
J X Song, and
Z Z Huang, and
Y M Wu, and
M J Yu
September 2003,
Phytotherapy research : PTR,
X M Zhu, and
J X Song, and
Z Z Huang, and
Y M Wu, and
M J Yu
April 1981,
Antimicrobial agents and chemotherapy,
