Biomaterial Database

[Whole-body autoradiographic localization of catecholamic acid in mice]. 1994

J S Zhang, and Y Y Liang, and X M Yan

Shanghai Institute of Materia Medica, Chinese Academy of Sciences.

Catecholamic acid [catechol-3,6-bis-(methyleneimino diacetic acid)] is a chelating agent synthesized in our institute. Whole-body autoradiographic study was carried out to determine the distribution of [14C]catecholamic acid in 5 adult male mice. Each mouse was injected i.v. 370 kBq. After various times the mice, under ether anesthesia, were immersed in a mixture of dry ice and hexane. Whole-body sections were made at -20 C, 20 microns in thickness. Results showed: (1) At 5 min, higher radioactivities appeared in blood, kidneys, gastrointestinal mucosa, bone, skin, and hair; moderate concentrations in liver, lungs, spleen, and salivary glands. (2) During 20 min and 3 h, the radioactivities decreased (gradually) in all tissues except the bone. (3) Intense radioactivity persisted in the bone, while only traces remained in the kidneys and intestinal mucosa throughout the 24 h period of observation.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D002396	Catechols	A group of 1,2-benzenediols that contain the general formula R-C6H5O2.	Pyrocatechols,o-Dihydroxybenzenes,ortho-Dihydroxybenzenes,o Dihydroxybenzenes,ortho Dihydroxybenzenes
D002614	Chelating Agents	Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.	Chelating Agent,Chelator,Complexons,Metal Antagonists,Chelators,Metal Chelating Agents,Agent, Chelating,Agents, Chelating,Agents, Metal Chelating,Antagonists, Metal,Chelating Agents, Metal
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001345	Autoradiography	The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)	Radioautography
D014018	Tissue Distribution	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.	Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus