-transparent.png){kind=logo}
A pharmacokinetic-pharmacodynamic cross-over study in a group of volunteers (8 male, 4 female) was performed to evaluate the activity and plasma levels of a new sustained-release metoclopramide (CAS 364-62-5) formulation (Cronoprimperan) in comparison to a standard formulation (Primperan). During the course of this trial volunteers on both medications complained of mild to moderate adverse effects as headaches and drowsiness. Elevated monocyte counts were seen in all volunteers at the end of the study without determinable relationship to the medications. No relevant differences were observed between the two preparations in the standard motor and coordination tests. The new sustained-release metoclopramide formulation showed 12-h coverage with a plateau shaped form for achieving constant blood levels throughout the day without reaching blood concentrations above clinically tolerable limits.
F J Harrison, and
F Heirler, and
J Scherer, and
A Wulsch, and
A Galiano, and
M Hornauer, and
J Kelly
January 1988,
Journal of pediatric gastroenterology and nutrition,
F J Harrison, and
F Heirler, and
J Scherer, and
A Wulsch, and
A Galiano, and
M Hornauer, and
J Kelly
January 2011,
Pharmaceutics,
F J Harrison, and
F Heirler, and
J Scherer, and
A Wulsch, and
A Galiano, and
M Hornauer, and
J Kelly
September 1993,
Age and ageing,
F J Harrison, and
F Heirler, and
J Scherer, and
A Wulsch, and
A Galiano, and
M Hornauer, and
J Kelly
November 1997,
Human reproduction (Oxford, England),
F J Harrison, and
F Heirler, and
J Scherer, and
A Wulsch, and
A Galiano, and
M Hornauer, and
J Kelly
November 1987,
British journal of clinical pharmacology,
F J Harrison, and
F Heirler, and
J Scherer, and
A Wulsch, and
A Galiano, and
M Hornauer, and
J Kelly
January 1979,
Lancet (London, England),
F J Harrison, and
F Heirler, and
J Scherer, and
A Wulsch, and
A Galiano, and
M Hornauer, and
J Kelly
July 2005,
Zhonghua yi xue za zhi,
F J Harrison, and
F Heirler, and
J Scherer, and
A Wulsch, and
A Galiano, and
M Hornauer, and
J Kelly
September 1991,
International journal of clinical pharmacology, therapy, and toxicology,
F J Harrison, and
F Heirler, and
J Scherer, and
A Wulsch, and
A Galiano, and
M Hornauer, and
J Kelly
May 1986,
Medicina clinica,
F J Harrison, and
F Heirler, and
J Scherer, and
A Wulsch, and
A Galiano, and
M Hornauer, and
J Kelly
June 1990,
Hospital practice (Office ed.),
