Biomaterial Database

Detoxification of citrinin and ochratoxin A by hydrogen peroxide. 1994

S G Fouler, and A B Trivedi, and N Kitabatake

Kyoto University, Research Institute for Food Science, Japan.

The effects of hydrogen peroxide on citrinin and ochratoxin A toxicity were examined using HeLa cells. The citrinin was completely detoxified by prior incubation with 0.05% hydrogen peroxide for 30 min at room temperature, and the toxic compound(s) that resulted from heating citrinin at 100 degrees C were also detoxified upon reheating it with hydrogen peroxide. On the other hand, ochratoxin A was not detoxified by hydrogen peroxide at room temperature, but its toxicity was reduced by heating ochratoxin A with hydrogen peroxide under alkaline conditions.

UI	MeSH Term	Description	Entries
D009793	Ochratoxins	Isocoumarins found in ASPERGILLUS OCHRACEUS and other FUNGI. Ochratoxin contaminated FOOD has been responsible for cases of FOODBORNE DISEASES.	Ochratoxin
D002470	Cell Survival	The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.	Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D002953	Citrinin	Antibiotic and mycotoxin from Aspergillus niveus and Penicillium citrinum.
D006358	Hot Temperature	Presence of warmth or heat or a temperature notably higher than an accustomed norm.	Heat,Hot Temperatures,Temperature, Hot,Temperatures, Hot
D006367	HeLa Cells	The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays.	Cell, HeLa,Cells, HeLa,HeLa Cell
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006861	Hydrogen Peroxide	A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.	Hydrogen Peroxide (H2O2),Hydroperoxide,Oxydol,Perhydrol,Superoxol,Peroxide, Hydrogen
D006863	Hydrogen-Ion Concentration	The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH	pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations