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There are 209 congeners of polychlorinated biphenyls (PCBs), the metabolism and toxicity of which vary by congeners. Use of PCBs is now restricted, but environmental contamination and human exposure persist. Analysis for "total PCBs" in biological samples gives limited information; congener-specific analysis is far more informative, but more complicated. Concentrations of congeners in serum/plasma, adipose tissue, or milk are useful biomarkers of exposure. Lipids may contain similar concentrations and congener patterns, but these vary between exposures and are different from those of the corresponding exposure mixtures; hence, analysis of lipids cannot be used to identify the original exposure. Some non- and mono-ortho congeners may attain a coplanar conformation, which renders them capable of a dioxin-like action. Toxic equivalency factors (TEFs) have been used to sum that risk as toxic equivalents (TEQs), which are considerably different from congener concentrations. No reliable data have been developed on the relationship between concentrations of "total PCBs" or congeners in biological samples and effects of PCBs on human health, mainly because of the various analytical procedures involved and confounding exposures.
S Skerfving, and
B G Svensson, and
L Asplund, and
L Hagmar
November 1989,
Lancet (London, England),
S Skerfving, and
B G Svensson, and
L Asplund, and
L Hagmar
January 1988,
American family physician,
S Skerfving, and
B G Svensson, and
L Asplund, and
L Hagmar
April 1987,
British journal of industrial medicine,
S Skerfving, and
B G Svensson, and
L Asplund, and
L Hagmar
May 1985,
Environmental health perspectives,
S Skerfving, and
B G Svensson, and
L Asplund, and
L Hagmar
July 2000,
American journal of epidemiology,
S Skerfving, and
B G Svensson, and
L Asplund, and
L Hagmar
May 1991,
Archives of environmental contamination and toxicology,
S Skerfving, and
B G Svensson, and
L Asplund, and
L Hagmar
December 1987,
Environmental health perspectives,
S Skerfving, and
B G Svensson, and
L Asplund, and
L Hagmar
October 1991,
Toxicology and applied pharmacology,
S Skerfving, and
B G Svensson, and
L Asplund, and
L Hagmar
February 1981,
British journal of industrial medicine,
S Skerfving, and
B G Svensson, and
L Asplund, and
L Hagmar
January 1987,
Journal - Association of Official Analytical Chemists,
