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The authors report the results of a randomised, multi-centric study comparing the antipyretic activity of tiaprofenic acid to that of acetaminophen. Seventy nine children of both sexes, aged 8 months to 9 years, having an average temperature at inclusion of 38.5 degrees C (+/- 0.5 degree C), received as a single dose 50 mg of tiaprofenic acid (3.7 +/- 0.9 mg/kg) (40 children) or 100 mg of acetaminophen (7.7 +/- 1.7 mg/kg) (39 children) for upper respiratory tract infection. The rectal temperature was taken regularly over a 6-hour period. Whatever the criteria considered (gradient between the initial temperature and the lowest temperature observed, difference of temperature at the different time points between the two groups), tiaprofenic acid appeared as effective an antipyretic as acetaminophen. Tolerance was good in both groups. Tiaprofenic acid appears as an interesting alternative to acetaminophen in the treatment of fever in upper respiratory tract infections in children.
J F Duhamel, and
M Guillot, and
J Brouard, and
S Debosque, and
L Consten, and
I Dresco, and
M Perret, and
Y Rezvani
January 1996,
Fundamental & clinical pharmacology,
J F Duhamel, and
M Guillot, and
J Brouard, and
S Debosque, and
L Consten, and
I Dresco, and
M Perret, and
Y Rezvani
November 2002,
Indian pediatrics,
J F Duhamel, and
M Guillot, and
J Brouard, and
S Debosque, and
L Consten, and
I Dresco, and
M Perret, and
Y Rezvani
April 1984,
Annales de pediatrie,
J F Duhamel, and
M Guillot, and
J Brouard, and
S Debosque, and
L Consten, and
I Dresco, and
M Perret, and
Y Rezvani
January 1985,
Drugs under experimental and clinical research,
J F Duhamel, and
M Guillot, and
J Brouard, and
S Debosque, and
L Consten, and
I Dresco, and
M Perret, and
Y Rezvani
December 1983,
Annales de pediatrie,
J F Duhamel, and
M Guillot, and
J Brouard, and
S Debosque, and
L Consten, and
I Dresco, and
M Perret, and
Y Rezvani
January 1984,
The Journal of international medical research,
J F Duhamel, and
M Guillot, and
J Brouard, and
S Debosque, and
L Consten, and
I Dresco, and
M Perret, and
Y Rezvani
October 1991,
L' Information dentaire,
J F Duhamel, and
M Guillot, and
J Brouard, and
S Debosque, and
L Consten, and
I Dresco, and
M Perret, and
Y Rezvani
November 1980,
La Clinica terapeutica,
J F Duhamel, and
M Guillot, and
J Brouard, and
S Debosque, and
L Consten, and
I Dresco, and
M Perret, and
Y Rezvani
April 1985,
The British journal of clinical practice,
J F Duhamel, and
M Guillot, and
J Brouard, and
S Debosque, and
L Consten, and
I Dresco, and
M Perret, and
Y Rezvani
December 1997,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
