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Rats with small (diam. 1.7 mm), medium sized (diam. 3.5 mm) or large (diam. 5.5 mm) corneal epithelial erosions in one eye were killed 1, 2 or 4 days after the injury. The proliferative response was evaluated by measuring the labelling index and the mitotic rate in the corneal epithelium and in the adjacent conjunctiva. The small erosions triggered a proliferative response in the cornea only with the maximum response occurring midperipherally. The medium sized erosions induced a higher and more extensive response in the cornea and also a slight increase of the labelling index in the limbal area. The large erosions induced an even more pronounced response in the peripheral cornea and an increase both of the labelling index and the mitotic rate well beyond the limbal part of the conjunctiva. It is concluded that the magnitude and the extent both of the conjunctival and the corneal regenerative response to a corneal abrasion is correlated to the size of the corneal defect. Temporary reduction in the conjunctival epithelial cell number shows that both cells in the limbal and the extralimbal conjunctiva migrate centripetally during healing of large corneal wounds. It is suggested that the stem cell theory should be modified. The limbal area is probably an area in which conjunctival epithelial cells or conjunctiva-derivated cells transform or differentiate to corneal epithelial cells.
K U Sandvig, and
E Haaskjold, and
R Bjerknes, and
S B Refsum, and
K Kravik
January 2013,
Molecular vision,
K U Sandvig, and
E Haaskjold, and
R Bjerknes, and
S B Refsum, and
K Kravik
August 1998,
Acta ophthalmologica Scandinavica,
K U Sandvig, and
E Haaskjold, and
R Bjerknes, and
S B Refsum, and
K Kravik
September 1987,
Investigative ophthalmology & visual science,
K U Sandvig, and
E Haaskjold, and
R Bjerknes, and
S B Refsum, and
K Kravik
March 2021,
NPJ Regenerative medicine,
K U Sandvig, and
E Haaskjold, and
R Bjerknes, and
S B Refsum, and
K Kravik
April 1989,
Acta ophthalmologica,
K U Sandvig, and
E Haaskjold, and
R Bjerknes, and
S B Refsum, and
K Kravik
August 1967,
Nippon Ganka Gakkai zasshi,
K U Sandvig, and
E Haaskjold, and
R Bjerknes, and
S B Refsum, and
K Kravik
May 1983,
Investigative ophthalmology & visual science,
K U Sandvig, and
E Haaskjold, and
R Bjerknes, and
S B Refsum, and
K Kravik
October 1974,
Investigative ophthalmology,
K U Sandvig, and
E Haaskjold, and
R Bjerknes, and
S B Refsum, and
K Kravik
February 1986,
Current eye research,
K U Sandvig, and
E Haaskjold, and
R Bjerknes, and
S B Refsum, and
K Kravik
April 2006,
Investigative ophthalmology & visual science,
