-transparent.png){kind=logo}
In order to determine the importance of the pyrrolic nitrogen atom in a series of suitably substituted gamma-carbolines derivatives for their cytotoxic and antitumor properties, a series of structurally related benz[h]isoquinolines were synthesized. When compared to the "parent" gamma-carbolines, these new compounds showed greatly decreased effects on topoisomerases I and II. Whereas the 8-hydroxylated derivatives retained a significant cytotoxicity, all the new compounds were devoid of antitumor effect in the P388 murine ip-ip system.
Related Publications
Y L Janin, and
D Carrez, and
J F Riou, and
E Bisagni
November 2019,
Molecules (Basel, Switzerland),
Y L Janin, and
D Carrez, and
J F Riou, and
E Bisagni
August 1964,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
Y L Janin, and
D Carrez, and
J F Riou, and
E Bisagni
August 2000,
Farmaco (Societa chimica italiana : 1989),
Y L Janin, and
D Carrez, and
J F Riou, and
E Bisagni
December 1995,
Arzneimittel-Forschung,
Y L Janin, and
D Carrez, and
J F Riou, and
E Bisagni
May 2005,
Bioorganic & medicinal chemistry,
Y L Janin, and
D Carrez, and
J F Riou, and
E Bisagni
October 2017,
Chemistry Central journal,
Y L Janin, and
D Carrez, and
J F Riou, and
E Bisagni
June 1979,
Il Farmaco; edizione scientifica,
Y L Janin, and
D Carrez, and
J F Riou, and
E Bisagni
February 2022,
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,
Y L Janin, and
D Carrez, and
J F Riou, and
E Bisagni
June 2014,
Artificial cells, nanomedicine, and biotechnology,
Y L Janin, and
D Carrez, and
J F Riou, and
E Bisagni
June 2023,
International journal of molecular sciences,
