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The 5'-flanking region of human Cu/Zn superoxide dismutase (SOD1) was cloned from human genomic library for the study of regulation of human SOD1 gene. We determined 3678 nucleotide sequences of 5'-flanking region of human SOD1. The putative binding sites of transcriptional factors such as NF1, Sp1, AP1, AP2, GRE, HSE and NF kappa B were found. The upstream region of this gene was analyzed by deletion and measuring the linked chloramphenicol acetyltransferase (CAT) activities. Several deletion analyses of promoter activity indicated that there were positive and negative regulatory regions. The region from -1325 bp to -1040 bp was found to have a heat shock response element.
H T Kim, and
Y H Kim, and
J W Nam, and
H J Lee, and
H M Rho, and
G Jung
June 1986,
Proceedings of the National Academy of Sciences of the United States of America,
H T Kim, and
Y H Kim, and
J W Nam, and
H J Lee, and
H M Rho, and
G Jung
December 1980,
FEBS letters,
H T Kim, and
Y H Kim, and
J W Nam, and
H J Lee, and
H M Rho, and
G Jung
June 2012,
International journal of clinical pharmacology and therapeutics,
H T Kim, and
Y H Kim, and
J W Nam, and
H J Lee, and
H M Rho, and
G Jung
January 1990,
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H T Kim, and
Y H Kim, and
J W Nam, and
H J Lee, and
H M Rho, and
G Jung
November 1988,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
H T Kim, and
Y H Kim, and
J W Nam, and
H J Lee, and
H M Rho, and
G Jung
September 2000,
Biochemical and biophysical research communications,
H T Kim, and
Y H Kim, and
J W Nam, and
H J Lee, and
H M Rho, and
G Jung
December 2006,
Free radical biology & medicine,
H T Kim, and
Y H Kim, and
J W Nam, and
H J Lee, and
H M Rho, and
G Jung
August 1996,
Proceedings of the National Academy of Sciences of the United States of America,
H T Kim, and
Y H Kim, and
J W Nam, and
H J Lee, and
H M Rho, and
G Jung
July 1987,
Nucleic acids research,
H T Kim, and
Y H Kim, and
J W Nam, and
H J Lee, and
H M Rho, and
G Jung
January 1991,
Comparative biochemistry and physiology. B, Comparative biochemistry,
