-transparent.png){kind=logo}
A number of quinolonyl-3'-penicillin and 4'-cephalosporin derivatives have been synthesised incorporating imino group of fluoroquinolone antibacterials, viz. norfloxacin and ciprofloxacin, into carboxylic acid group of a number of semisynthetic penicillins and cephalosporins via their mixed anhydride, thereby forming an amide linkage at 3 and 4 position of the penicillin and cephalosporin component, respectively. The structure of these compounds was confirmed by spectral data and elemental analysis. The antibacterial activity of the compounds in vitro were investigated against some bacterial strains by agar plate diffusion method. While most of the compounds showed broad spectrum activity, compounds VIa and VIb exhibited higher activity against Ps. aeruginosa, K. pneumoniae and S. aureus than that of norfloxacin suggesting a dual mode of action. No untoward reaction was observed during toxicity studies of the compounds upto 1 g/kg body weight by oral route in albino mice.
S K Bhanot, and
N R Chatterjee, and
S R Naik
December 2003,
Farmaco (Societa chimica italiana : 1989),
S K Bhanot, and
N R Chatterjee, and
S R Naik
October 2003,
Archives of pharmacal research,
S K Bhanot, and
N R Chatterjee, and
S R Naik
April 2010,
Molecules (Basel, Switzerland),
S K Bhanot, and
N R Chatterjee, and
S R Naik
April 2010,
Bioorganic & medicinal chemistry,
S K Bhanot, and
N R Chatterjee, and
S R Naik
January 2014,
Scientia pharmaceutica,
S K Bhanot, and
N R Chatterjee, and
S R Naik
February 1993,
Die Pharmazie,
S K Bhanot, and
N R Chatterjee, and
S R Naik
July 1996,
Farmaco (Societa chimica italiana : 1989),
S K Bhanot, and
N R Chatterjee, and
S R Naik
January 2012,
Iranian journal of pharmaceutical research : IJPR,
S K Bhanot, and
N R Chatterjee, and
S R Naik
October 1998,
Die Pharmazie,
S K Bhanot, and
N R Chatterjee, and
S R Naik
August 1997,
Die Pharmazie,
