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1. Glutathione (GSH), injected by slow intravenous (i.v.) infusion (7.9 microliters/min, for 4 hr; total dose: 1.5 g/kg), starting 10 min after i.v. injection of kainic acid (KA; 12 mg/kg) in the rat reduced the decrease in local cerebral glucose utilization observed 48 hr following the administration of the neurotoxin. 2. Furthermore, it blocked the neuronal loss in hippocampal CA1 and CA3 regions, and prevented, in the hippocampus, the development of edema and the marked depletion in the endogenous brain GSH pool. 3. One can speculate that this protective effect of exogenous GSH is correlated to its capacity to scavenge free radicals, thus preventing the accumulation of oxidant chemical species and the consequent reduction of cellular antioxidant defense.
A Saija, and
P Princi, and
A Pisani, and
M Lanza, and
M Scalese, and
E Aramnejad, and
R Ceserani, and
G Costa
June 2000,
Neuroscience letters,
A Saija, and
P Princi, and
A Pisani, and
M Lanza, and
M Scalese, and
E Aramnejad, and
R Ceserani, and
G Costa
October 1987,
Brain research,
A Saija, and
P Princi, and
A Pisani, and
M Lanza, and
M Scalese, and
E Aramnejad, and
R Ceserani, and
G Costa
October 2011,
Neuroscience,
A Saija, and
P Princi, and
A Pisani, and
M Lanza, and
M Scalese, and
E Aramnejad, and
R Ceserani, and
G Costa
February 2003,
European journal of pharmacology,
A Saija, and
P Princi, and
A Pisani, and
M Lanza, and
M Scalese, and
E Aramnejad, and
R Ceserani, and
G Costa
May 1991,
Agents and actions,
A Saija, and
P Princi, and
A Pisani, and
M Lanza, and
M Scalese, and
E Aramnejad, and
R Ceserani, and
G Costa
December 1997,
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
A Saija, and
P Princi, and
A Pisani, and
M Lanza, and
M Scalese, and
E Aramnejad, and
R Ceserani, and
G Costa
June 2002,
Neuroscience letters,
A Saija, and
P Princi, and
A Pisani, and
M Lanza, and
M Scalese, and
E Aramnejad, and
R Ceserani, and
G Costa
January 1997,
Epilepsia,
A Saija, and
P Princi, and
A Pisani, and
M Lanza, and
M Scalese, and
E Aramnejad, and
R Ceserani, and
G Costa
January 2008,
Epilepsia,
A Saija, and
P Princi, and
A Pisani, and
M Lanza, and
M Scalese, and
E Aramnejad, and
R Ceserani, and
G Costa
May 2015,
European journal of pharmacology,
