-transparent.png){kind=logo}
Antisera to each of the three main cytosolic forms of glutathione S-transferase (GST; alpha, mu, and pi) has been used to characterise GST expression by metastatic neuroblastoma in bone marrow trephine biopsies taken from 15 patients at presentation and from five of this group at relapse. There was no correlation between expression of extra-nuclear alpha or mu GST and outcome, and no consistent pattern at relapse. Seven of eight expressing nuclear pi GST at presentation died of resistant disease. Three of five cases with no detectable nuclear pi class GST remain alive and disease free. The results provide no encouragement for further investigation of alpha or mu GST in this disease but larger studies of uniformly treated patients may show whether nuclear pi GST expression at presentation indicates likely relapse.
A G Hall, and
A G McGuckin, and
A D Pearson, and
A R Cattan, and
A J Malcolm, and
M M Reid
June 2005,
Pharmacogenetics and genomics,
A G Hall, and
A G McGuckin, and
A D Pearson, and
A R Cattan, and
A J Malcolm, and
M M Reid
January 2014,
PloS one,
A G Hall, and
A G McGuckin, and
A D Pearson, and
A R Cattan, and
A J Malcolm, and
M M Reid
January 2002,
Pediatric hematology and oncology,
A G Hall, and
A G McGuckin, and
A D Pearson, and
A R Cattan, and
A J Malcolm, and
M M Reid
January 2015,
PloS one,
A G Hall, and
A G McGuckin, and
A D Pearson, and
A R Cattan, and
A J Malcolm, and
M M Reid
January 1990,
Journal of clinical pathology,
A G Hall, and
A G McGuckin, and
A D Pearson, and
A R Cattan, and
A J Malcolm, and
M M Reid
June 1994,
International journal of oncology,
A G Hall, and
A G McGuckin, and
A D Pearson, and
A R Cattan, and
A J Malcolm, and
M M Reid
August 1999,
Nihon rinsho. Japanese journal of clinical medicine,
A G Hall, and
A G McGuckin, and
A D Pearson, and
A R Cattan, and
A J Malcolm, and
M M Reid
September 2004,
Blood,
A G Hall, and
A G McGuckin, and
A D Pearson, and
A R Cattan, and
A J Malcolm, and
M M Reid
June 1998,
Cancer research,
A G Hall, and
A G McGuckin, and
A D Pearson, and
A R Cattan, and
A J Malcolm, and
M M Reid
April 1985,
Cancer research,
