Biomaterial Database

[Evaluation of pulmonary elastance and resistance in acute pancreatitis. Experimental study in rats]. 1993

E Chaib, and P H Saldiva, and P M Criado, and R S Sakae, and M C Machado

Departamento de Patologia da Faculdade de Medicina, Universidade de São Paulo.

Approximately 50 to 70% of the patients with acute pancreatitis (AP) have suffered hypoxia and 1/3 of the pulmonary lesions could progress to a clinical respiratory insufficiency. The respiratory mechanics has been studied by Amdur and Mead (1958) method in the rat with acute pancreatitis induced by taurocholate acid injection into hepatic duct. It has been measured dynamic elastance and pulmonary resistance. Three groups were studied: control group "sham operation"-12 rats; 2 hours pancreatitis group-10 rats and 8 hours pancreatitis group-8 rats. There was no significant increase on dynamic elastance in 2 hours AP group and also no tendency of normalization of this parameter in 8 hours AP group. The pulmonary resistance shows no significant increase in 2 and 8 AP groups (p). The pulmonary resistance alterations show that AP does not lead to an obstructive pneumophathy and if correlated with the decrease of total pulmonary capacity observed in the volume/pressure curves one could conclude that AP probably is associated with a restrictive pneumophathy.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010195	Pancreatitis	INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.	Acute Edematous Pancreatitis,Acute Pancreatitis,Pancreatic Parenchyma with Edema,Pancreatic Parenchymal Edema,Pancreatitis, Acute,Pancreatitis, Acute Edematous,Peripancreatic Fat Necrosis,Acute Edematous Pancreatitides,Acute Pancreatitides,Edema, Pancreatic Parenchymal,Edematous Pancreatitides, Acute,Edematous Pancreatitis, Acute,Fat Necrosis, Peripancreatic,Necrosis, Peripancreatic Fat,Pancreatic Parenchymal Edemas,Pancreatitides, Acute,Pancreatitides, Acute Edematous,Parenchymal Edema, Pancreatic,Peripancreatic Fat Necroses
D006470	Hemorrhage	Bleeding or escape of blood from a vessel.	Bleeding,Hemorrhages
D000208	Acute Disease	Disease having a short and relatively severe course.	Acute Diseases,Disease, Acute,Diseases, Acute
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D015656	Respiratory Mechanics	The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.	Breathing Mechanics,Breathing Mechanic,Mechanic, Breathing,Mechanic, Respiratory,Mechanics, Breathing,Mechanics, Respiratory,Respiratory Mechanic
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus