Single photon emission computed tomography with [99Tc]-HM-PAO and [123I]-IBZM in Alzheimer's disease and dementia of frontal type: preliminary results. 1994

G B Frisoni, and G Pizzolato, and A Bianchetti, and F Chierichetti, and G Ferlin, and L Battistin, and M Trabucchi
Alzheimer's Disease Care Unit, Ist. S. Cuore-FBF, Brescia, Italy.

Dementia of frontal type (DFT) is a fairly common degenerative disease distinct from Alzheimer's disease (AD), whose reportedly distinctive instrumental feature is frontal lobe hypoperfusion on SPECT. We evaluated the cortical dopaminergic system in 6 AD, 5 DFT, and 6 control subjects with SPECT and both [99Tc]-HM-PAO, a perfusion tracer, and [123I]-IBZM, a D2 postsynaptic ligand. Both in AD and DFT patients, [99Tc]-HM-PAO SPECT showed a relative frontal hypoperfusion. On the contrary, [123I]-IBZM SPECT showed significantly reduced ligand uptake in superior frontal regions of DFT (0.89 +/- 0.08 relative to control subjects) as compared to AD patients (0.97 +/- 0.02; difference of means: 0.08, 95% Confidence Interval 0.004 to 0.156; p = 0.041). Results suggest more marked involvement of the frontal cortical dopaminergic system in DFT than in AD patients.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011954 Receptors, Dopamine Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells. Dopamine Receptors,Dopamine Receptor,Receptor, Dopamine
D002531 Cerebellum The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills. Cerebella,Corpus Cerebelli,Parencephalon,Cerebellums,Parencephalons
D002552 Cerebral Ventricles Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE). Foramen of Monro,Cerebral Ventricular System,Cerebral Ventricle,Cerebral Ventricular Systems,Monro Foramen,System, Cerebral Ventricular,Systems, Cerebral Ventricular,Ventricle, Cerebral,Ventricles, Cerebral,Ventricular System, Cerebral,Ventricular Systems, Cerebral
D002555 Cerebrospinal Fluid A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES. Cerebro Spinal Fluid,Cerebro Spinal Fluids,Cerebrospinal Fluids,Fluid, Cerebro Spinal,Fluid, Cerebrospinal,Fluids, Cerebro Spinal,Fluids, Cerebrospinal,Spinal Fluid, Cerebro,Spinal Fluids, Cerebro
D003704 Dementia An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness. Senile Paranoid Dementia,Amentia,Familial Dementia,Amentias,Dementia, Familial,Dementias,Dementias, Familial,Dementias, Senile Paranoid,Familial Dementias,Paranoid Dementia, Senile,Paranoid Dementias, Senile,Senile Paranoid Dementias
D005260 Female Females
D005625 Frontal Lobe The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus. Brodmann Area 8,Brodmann's Area 8,Frontal Cortex,Frontal Eye Fields,Lobus Frontalis,Supplementary Eye Field,Area 8, Brodmann,Area 8, Brodmann's,Brodmanns Area 8,Cortex, Frontal,Eye Field, Frontal,Eye Field, Supplementary,Eye Fields, Frontal,Frontal Cortices,Frontal Eye Field,Frontal Lobes,Lobe, Frontal,Supplementary Eye Fields
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

G B Frisoni, and G Pizzolato, and A Bianchetti, and F Chierichetti, and G Ferlin, and L Battistin, and M Trabucchi
January 1989, Revue neurologique,
G B Frisoni, and G Pizzolato, and A Bianchetti, and F Chierichetti, and G Ferlin, and L Battistin, and M Trabucchi
February 1991, The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques,
G B Frisoni, and G Pizzolato, and A Bianchetti, and F Chierichetti, and G Ferlin, and L Battistin, and M Trabucchi
April 1990, Acta neurologica Scandinavica,
G B Frisoni, and G Pizzolato, and A Bianchetti, and F Chierichetti, and G Ferlin, and L Battistin, and M Trabucchi
September 1987, Journal of neurology, neurosurgery, and psychiatry,
G B Frisoni, and G Pizzolato, and A Bianchetti, and F Chierichetti, and G Ferlin, and L Battistin, and M Trabucchi
January 1990, Neuroradiology,
G B Frisoni, and G Pizzolato, and A Bianchetti, and F Chierichetti, and G Ferlin, and L Battistin, and M Trabucchi
April 1989, Italian journal of neurological sciences,
G B Frisoni, and G Pizzolato, and A Bianchetti, and F Chierichetti, and G Ferlin, and L Battistin, and M Trabucchi
May 1992, Archives of neurology,
G B Frisoni, and G Pizzolato, and A Bianchetti, and F Chierichetti, and G Ferlin, and L Battistin, and M Trabucchi
December 1984, Lancet (London, England),
G B Frisoni, and G Pizzolato, and A Bianchetti, and F Chierichetti, and G Ferlin, and L Battistin, and M Trabucchi
October 1996, Neurology,
G B Frisoni, and G Pizzolato, and A Bianchetti, and F Chierichetti, and G Ferlin, and L Battistin, and M Trabucchi
April 1993, Journal of neuroimaging : official journal of the American Society of Neuroimaging,
Copied contents to your clipboard!