Biomaterial Database

Variation in results of cost-effective EMIT assays on the Cobas-Bio analyser. 1993

F M Moore, and D Simpson

Department of Clinical Chemistry, Royal Infirmary, Edinburgh, Scotland, UK.

Following suggestions that spurious results occur with EMIT assays--so-called 'fliers'--many laboratories perform such assays in duplicate. In this study, using a Cobas-Bio centrifugal analyser and cost-effective assays developed in the authors' laboratory, complete EMIT assays were run, each with its own calibration curve, on three anti-epileptic drugs using plasma samples, and five drugs of abuse using urine samples. No serious spurious results were obtained. It is suggested that there is no inherent tendency for EMIT assays to produce 'fliers' and that when these occur they may be explained by factors common to many other types of assay.

UI	MeSH Term	Description	Entries
D003362	Cost-Benefit Analysis	A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. In contrast a cost effectiveness in general compares cost with qualitative outcomes.	Cost and Benefit,Cost-Benefit Data,Benefits and Costs,Cost Benefit,Cost Benefit Analysis,Cost-Utility Analysis,Costs and Benefits,Economic Evaluation,Marginal Analysis,Analyses, Cost Benefit,Analysis, Cost Benefit,Analysis, Cost-Benefit,Analysis, Cost-Utility,Analysis, Marginal,Benefit and Cost,Cost Benefit Analyses,Cost Benefit Data,Cost Utility Analysis,Cost-Benefit Analyses,Cost-Utility Analyses,Data, Cost-Benefit,Economic Evaluations,Evaluation, Economic,Marginal Analyses
D001322	Autoanalysis	Method of analyzing chemicals using automation.	Autoanalyses
D015203	Reproducibility of Results	The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.	Reliability and Validity,Reliability of Result,Reproducibility Of Result,Reproducibility of Finding,Validity of Result,Validity of Results,Face Validity,Reliability (Epidemiology),Reliability of Results,Reproducibility of Findings,Test-Retest Reliability,Validity (Epidemiology),Finding Reproducibilities,Finding Reproducibility,Of Result, Reproducibility,Of Results, Reproducibility,Reliabilities, Test-Retest,Reliability, Test-Retest,Result Reliabilities,Result Reliability,Result Validities,Result Validity,Result, Reproducibility Of,Results, Reproducibility Of,Test Retest Reliability,Validity and Reliability,Validity, Face
D017248	Enzyme Multiplied Immunoassay Technique	An immunoenzyme test for the presence of drugs and other substances in urine and blood. The test uses enzyme linked antibodies that react only with the particular drug for which the sample is being tested.	EMIT Assay,Assay, EMIT,Assays, EMIT,EMIT Assays